Clinical And Experimental Study On Therapy Acute Cholangitis Of Severe Type With The Method Of Clearing Away Pathogenic Heat And Toxic Waterial And Purgation

Acute cholangitis of severe type(ACST) is a kind of dangerously common encountered acute abdomen. At the present time, according to ACST, the main therapy is operation,which is combined with antibiotics. Recently,following the development of molecular-biology, Bacterial translocation and endotoxemia, which resulting from ACST, can lead to systemly inflammatory reaction syndrome(SIRS), and multi-organ dysfunctions(MODS). Some experimental researches have showed that some Chinese herbal drugs have notable effects in the treatment of acute abdomen, which can reduce endotoxin content in peripheral blood and regulate some inflammatory mediator's overexpress.In the clinical part of this research, The principle of treatment is clearing away pathogenic heat and toxic waterial and purgation. Though nasal feeding or enema, the result shows exact and satisfactory curative effect. The total effective rate reach 80.49%, which is much better than the contrasting group by traditional routine treatment. And this therapeutic plan has no obvious toxic side effects. Through injecting bacillus coli into the bile duct to make animal model, the experimental part of research shows that this way has many functions, such as anti-inflammation, prohibiting bacterial translocation, inhibiting inflammatory mediators' overexpress, and improving the resumption of gastrointestinal functions and liver functions. This thesis discuss the relative problems of research in base of Chinese and modern medical theories.