| The autoimmune disease is a kind of diseases that the organism autoimmune responses lose control and or overreacte, destroy self-tissue directly or indirectly, and arose pathological change of relevant organs or clinical symptoms, by intrinsic and extrinsic factors acting together. Systemic Lupus Erythematosus (SLE) and Primary Biliary Cirrhosis (PBC) are two different types of autoimmune diseases. Because of the disproportion of the T-cell subgroup, and Th1/Th2 cells disproportion in vivo, auto response T-cell proliferate, induce the B-cell activation, produce a great deal of autoantibody, form immune complex, injure the organism autoimmune system and lead to cellular immunity and humoral immunity dysfunction, and then cause the autoimmune diseases. This experiment determinate the autoantibody level in the serum and immunofluorescent patterns, circulating immunocomplex (CIC), serum C reactive protein (CRP), immunoglobulin (IgG, IgA, IgM) Complement (C3, C4) of 30 SLE patients and 30 PBC patients in our hospital and Dikuang Hospital, and the level of cytokine (IL-2, IL-4, TNF-α, IFN-γ) secreted by monocyte in the venous blood of part of the patients. And compared with the normal control group, it indicates that by the intrinsic and extrinsic factors act ing together, the organism autoimmune responses lose control, lead to the immunologic function injury, and then cause the autoimmune diseases. SLE is a kind of systemic immune disease, whose characteristic are polyclonal B cells activation and produced sorts of autoantibody. The serums of SLE patients contain several kinds of autoantibody in this experiment, thereinto the dsDNA antibody that has the obvious correlation with the activation of the disease, is the specific antibody. High concentration of CRP in serum indicates that the SLE patients immunologic function is the SLE patients disorder, and they are easily infected and have the correlation with the activation of the disease. The raise of immunoglobulin reported in literature doesn't exist in the experiment. The decreases of the complement content confirm that the activation of the complement system and immunologic function injury does exist in SLE patients. The level of cytokine (IL-2, TNF-α, IFN-γ) secreted by monocyte in the venous blood are obviously lower than the normal control group, but the level of IL-4 is apparent higher than the control. Those research shows that there are many kinds of dysimmunity, disequilibrium of Th subgroup, Th1/Th2 dysfunction (Th2 hyperfunction and Th1 hypofunction), result in the cytokine meshwork dysfunction, B-cell over activation, produce sorts of autoantibody and immunologic dysfunction in SLE. PBC is a kind of chronic intrahepatic cholangitis caused by autoimmunity, whose characteristics are the injury of middle and small intrahepatic duct. It is an organ specific autoimmunity disease. The research indicates that the main diagnosis standard of PBC is the high concentration of anti-mitochondrial antibody in the serum of the patients, and it is the same with the reports from native or abroad. The level of cytokine (IL-2, IL-4, TNF-α, IFN-γ) secreted by monocyte in the venous blood of PBC patients shows that there are two different types of T-cell subgroup. And compared with the normal control group, there are different kinds of cytokines secreted in PBC, and the cytokines unbalance also exists. The increase of TNF-αactivate the T-cell to secrete the IL-2, IFN-γand other cytokines, and participate in the inflammatory process of immunoloregulation all the time. The high concentration of immunoglobulin also confirmed that there are the cellular dysimmunity and the humoral dysimmunity at the same time. Those two dysimmunity synchronously action becomes the basis of the PBC occurring. Above all, the autoimmunity disease is from the abnormal immune response caused by the activated T-cell and its cytokine. The main abnormity of immune system is the T depended B-cell hyperfunction, and secretes a great deal of autoantibody and immu... |
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