| Hypoxic-ischemic encephalopathy (HIE) is the most common brain injured disease in neonatal period. Its morbility; mortality and incidence rate of sequela are all high. In these years its case fatality rate has taken on downtrend with the development of salvage therapy and monitoring measures, but the survivors from moderate and severe HIE are still likely to remain different sequelaes of nervous system, which always appear after neonatal period gradually and are detected by some parents when the babies are 6 months old, sometimes even 1 year old, but at this time the best treatment chance has been missed. The present study shows that after the hypoxic-ischemic brain injure, the death of neurons include two phases, Necrosis and Apoptosis, and the latter occurs in several hours after hypoxic-ischemic brain injure happens, it lasts long time, and is a slowly progressed and reversible course. The recovery of brain cells start from neonatal period and last to several weeks, monthes or even longer time after neonatal period because of the durative exist of Apoptosis. Early intervention that bases on the priciples and rules of children's nerve physiology and nerve development utilizes various measures to stimulate the neurons in the motion and apperception passageways, is a kind of ealy precaution convalescence treatment technology. Early intervention was used to educate and train the hypophrenia children initially, but in these years, it has been gradually utilized in the clinical therapy of HIE because the happeness of sequels of the moderate and severe HIE was not decreased well even when active drug treatment has been used in neonatal period. The theory base of eary intervention is that the compensation and plasticity of the nerve system are both best before 2 years old. The local injured cells's function can be replaced by the cells nearby, and these will make it's vicinity perform effective reorganization. In addition, nerve cells can make damaged structure adapt functionalily and make the function of brain cells get well compensation by the start using secondary passageway, synapse chit, bypassing project of axis cylinder, appearance of cytodendrite's unwonted bifurcation and creation of unconventional nerve synapse. These compensation ability will weaken obviously after the development of brain mature, therefore affluent enviroment stimulus and nursing stimulus with purpose and plan before 2 years old both have important contribution to the function and structure of brain not only in the physiology aspect but in the biochemistry aspect. The purpose of this study is to find the high risk factors on prognosis of HIE and take them as the objective foundation of carrying out early intervention. The early intervention is carried out in the patients who suffered from HIE with these factors while they accept the drug treatment in neonatal period, then discuss the effect of early intervention to the intellectal development; motor development and sequels. First, 49 cases who suffered from HIE and accepted treatment in our department from Spt. 2000 to Nov. 2000 were followed up and analyzed retrospectively at 1 year old in the study. Their clinical data were integrated. They were divided into observation group and control group according to whether the prognosis was abnormal. Data were compared between two group in 1 minute and 5 minute Apgar scores, the activity of CK-BB in serum in 24 hours after birth, clinical graduation, CT graduation on 7th day after birth and NBNA scores on 14th day after birth to screen the high risk factors on prognosis of HIE. According to the results 88 moderate and severe HIE cases who had at least one of upper risk factors were choosed from the patients who accepted treatment in our department from Dec. 2000 to Apr. 2001. They were divided into ealy intervention group and control group randomly.The early intervention group began to accept the early intervention after the pathogenetic condition was stable from the neonatal period to 2 years old, in addition,...
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