Intraperitoneal Chemotherapy For Treatment Of Twenty-five Patients With Primary Liver Cancer

Objective To evaluate the effect of intraperitoneal chemotherapy for treatment of cases of primary liver cancer(PLC) with metastasis within the abdominal cavity. Methods Intraperitoneal chemotherapy was performed in twenty-five patients with PLC with metastasis within the abdominal cavity. They were given a continuous intraperitoneal perfusion of 5-FU(0.5-0.75g/d ) up to a total dosage 8.0-9.75g during 10-15 days. This was followed by MMC l0mg intraperitoneal perfusion on the final day. A intraperitoneal perfusion of gemcitabine(800-1000mg) was given synchronously in three patients with cholangiocarcinoma. Results Complete response was achieved in 2 patients, partial response in 5, stable disease in 7 and progressive disease in. The total effective rate was 56%. Conclusions Intraperitoneal chemotherapy is an effective method for treatment of the patients with PLC with metastasis within the abdominal cavity.