Expression And Significance Of Angiopoietin-1, 2 And Their Recepter Tie-2 In Oral Squamous Cell Carcinoma

Objective:Expression of angiopoietin-1,2 and tie-2 were detected in oralsquamous cell carcinoma to explor the role of angiopoietins and their receptorTie-2 in oral squamous cell carcinoma. Methods:Angiopoietin-1,2, Tie-2 andCD34 protein expression in 34 oral squamous cell carcinomas and 16 oraleumucosa were investigated by immunohistochemical technique. All cases hadn'tradiation therapy and chemotherapy. Pathological classification of oral squamouscell carcinoma were :I:11；II:19；III:4. The expression of CD34 tells us theamount of angiogenesis. Results: It was found Ang-1 expressed alike in oralsquamous cell carcinomas and chronic oral mucositis (P>0.05).Ang-2 expressedat low level in chronic oral mucositis while strongly positive in oral squamouscell carcinomas and the level of Ang-2 expression in oral squamous cellcarcinomas was related with pathological classification: III (42.00±8.96/HP) > II(30.74±5.76/HP) > I (25.73±4.86/HP) (P<0.05). Tie-2 expressed at higher level inoral squamous cell carcinomas than in chronic oral mucositis (P<0.05), but notrelated with pathological classification (P>.05). CD34 expressed as Tie-2.Conclusions: Angiogenesis increased in oral squamous cell carcinomas; Ang-2expression in oral squamous cell carcinomas is related with angiogenesis andpathological classification, which is probably involved in angiogenesis regulation,promote the development and metastasis of oral squamous cell carcinomas.