The Influence Of Rosiglitazone On The Metabolism And Reproduction Of Polycystic Ovarian Syndrome

Polycystic ovarian syndrome(PCOS) is a genitalis endocrine disturbance disease which is common in women of reproductive age. Recent studies have demonstrated that insulin resistance and hyperinsulinism play a key role in the pathogenesis of polycystic ovary syndrome. It causes hyperandrogenism and high luteinizing hormone,amenorrhea and infertility. On the other hand,it causes the glycolipids metabolism disturbance and the metabolism complication,such as diabetes mellitus(DM), coronary heart disease(CHD), hypertension. Therefore the treatment of improving insulin sensitivity has opened a new therapeutic perspective as to polycystic ovary syndrome.Rosiglitazone is one of the insulin-sensitizing compounds, thiazolidinediones (TZDs), is a ligand for peroxisome proliferator activated receptor gamma (PPARgamma) . Rosiglitazone was given to the patients with PCOS in this investigation.Before and after treatment, BMI,WHR, blood pressure,blood sugar, insulin, proinsulin, HOMA-IR,PAI-l,TQTC,HDL,LDL,IGF-l,sex hormones,ovulation rate,liver and renal function were determined and compared.The aim is to observe the action of rosiglitazone on the insulin resistance and sex hormones disturbance of polycystic ovary syndrome.PI is one of the markers to reflect the disfunction of pancreatic islets cell.It is also the independent risk factor of diabetes mellitus.lt was reported that CHD has more close relation with PI than insulin.Does the auxoexcretion of PI exist in PCOS? The relationship between PI and PCOS and the influence of rosiglitazone on PI have not be reported in Chinese and foreign journals.PAI-1 is an important agent to adjust fibrinolysis activity.The increase of the activity and the level of PAI-1 indicate the independent risk factor of the occurrence embolism disease ,such as coronary heart disease.In resent years,some investigations manifested that the incidence of cardia-cerebrovascular disease obviously increase in insulin resistance patients in which PAI-1 played an important role. Whether the Level of PAI-1 increased in PCOS and the relationship between PAI-1 and IR, hypertension,CHD,lipid metabolism disorder,DM and the effect of rosiglitazone on PAI-1 will be detected.lt may be advantageous to prevent the metabolism complication. Scarcely is it reported in Chinese and foreign journals.IGF-1 can directly stimulate theca cell to synthesis androgen. It also produces a synergic effect with LH on the synthesis of androgen.Tbis investigation reviews the change of IGF-1 between pretreatment and post-treatment and the relationship between IGF-1 and reproductive honnones,the rate of ovulation.MethodsSubjects were divided into six groups: (1) The normal nonobese group(n=10); (2) The normal obese group(n=10); (3) The nonobese patients of PCOS group(n=20); (4) The obese patients of PCOS group(n=28); (5) The post-treatment nonobese patients of PCOS group(n=20); (6)The post-treatment obese patients of PCOS group(n=28).Rosiglitazone was given 4mg every day to 30 patients with PCOS for 12 weeks. PI,PAI-1,IGF-1 were measured by use of a sensitive enzyme-linked immunoadsordent assay .All experimental data were analyzed using ANOVA test ,LSD test,Pearson test and processed by SPSS10.0.There was a statistical significance when P<0.05.ResultsThere was significant difference between III group and I group, III group and IV group. III group and V group, IV group and II group. IV group and VI group in PI,FINS,HOMA-IR,PAI-1 (P <0.05). There was significant difference between III group and IV group, IV group and VI group in FPG,SBP, TG,TC (P <0.05). There was significant difference between III group and IV group, IV group and II group in DBP ( P <0.05 ) . There was significant difference between III group and I group. III group and IV group in IGF- 1 (P<0.05). There was significant difference between III group and I group, III group and IV group, IV group and II group, IV group and VI group in T (P<0.05). There was significant difference between III group and I group, III group and V group, IV group and II group, IV group...