Expression And Significance Of Leptin Receptor In Colorectal Adenocarcinoma

AIM: To investigation the expression of leptin receptor in colorectal cell lines and colorectal adenocarcinoma tissue, and the relationship between its expression, vascular proliferation and tumor cell proliferation.METHODS: The expression of leptin receptor was detected by immunohistochemistry. The CD34 and Ki67 proteins were marked by immunohistochemistry. leptin receptor, the MVD and cell proliferation exponent were analyzed by image analysis software.RESULTS: Leptin receptor was expressed in HT29 cells, SW480 cells and all colorectal adenocarcinoma tissue. The normal large intestine tissue had leptin receptor too, but the mean of their absorbance was lower than that of colorectal adenocarcinoma tissue (0.153 + 0.011 vs 0.115 + 0.071, P<0.05). The MVD and Ki67 exponent of colorectal adenocarcinoma tissue were both higher than that of normal controls (41.500+10.700 vs 31.300 11.100, P<0.01; 0.458 0.108 vs 0.312 0.097, P<0.01). There were positive correlation between leptin receptor and Ki67 exponent (r=0.388, P<0.05). The MVD of colorectal adenocarcinoma tissue which leptin receptor expressed in blood vessel endothelial cells was higher than the negative ones(45.100 10.000 vs 37.400 10.200, P<0.05). The correlation could not be found between leptin receptor and clinical pathology agent of colorectal adenocarcinoma.CONCLUSION: Leptin may have some roles to accelerate tumor cell proliferation and vascular proliferation in colorectal adenocarcinoma tissue after it bind leptin receptor.