| Medication leads drug eruption by breath in injection and so on. It leads inflammation on skin and mucous, and it may lead death. In recent years, the incidence of EE and TEN, which influences human's health and qualify of life. Many scholars are studying the mechanism of EE both domestic and abroad. They find that cytokine play an important role during the formation of dermatic inflammation of EE and TEN.This article study the function TNF-α,IL-8 in the occurrence of EE, both of which is a kind of cytokines household.Objective:The study uses enzyme linked immunosorbent assay(ELISA) to detect the level of TNF-α and IL-8 in the serum of 26 examples that use the medicine that and didn't not lead drug eruption.and 30 normal persons and 50 persons with EE and 8 persons With TEN. Group of patients compare with group of contrast. The relativity between the level of TNF-α and IL-8 and skin lesion is analyzed to probe the function of .TNF-αand IL-8 in the occurrence of EE and TEN. Method:We selected 58 patients with drug eruption who were in-patients in 2nd hospital of JiLin University and Liao Yuan city hospital from May 2001 to November 2003. All patients selected had no treatment of corticosteroid hormone, immunosuppression and antihistamines within 3 weeks. Get blood of vein in morning. And all reserved at -25℃Result:level of serum TNF-αfor patient group and control group About EE . 5o patient were adopted blood in first week, 32 patients were adopted blood in second week, 15 patients were adopted blood in fourth week, result is that TNF-α's level of comparing between control group A compared with control group B level of serum TNF-α. Have no a little change. t=0.48 P>0.05 EE. Group patients of first week compare control group A and B. t=15.43,18.69 P<0.01; patients of second week individual compare with control group A and B t=12.76,16.34 P<0.01; patients of fourth week. Compare with control group A t=8.65 P<0.01 , Compare with control group B t=2.91 P>.05; TNE: 8 examples were adopted blood in first week. 8 examples were adopted blood in second week. 5 examples were adopted blood in third week. 5 examples were adopted blood in fourth week. Level of patients in TNF-αfor patients in first week compare with patients in second week. patients in second week compare with patients in third week. Patients third week compare with patients in fourth week.form first week to fourth week is t=4.97,5.33,2.79 there is significant different.level of serum IL-8 for patient group and control group About EE. result is that IL-8's level of comparing between control group A compared with control group B level of serum IL-8. Have no a little change. t=0.39 P>0.05 EE. Group patients of first week compare control group A and B. t=22.49,27.91 P<0.01; patients of second week individual compare with control group A and B t=33.16,14.1 P<0.01; patients of fourth week. Compare with control group A t=11.34 P<0.01 , Compare with control group B t=0.41 P>.05; TEN: Level of patients in IL-8 for patients in first week compare with patients in second week. patients in second week compare with patients in third week. Patients third week compare with patients in fourth week.form first week to fourth week is t=8.79,3.04,2.42 there is significant different.Discussion: Machanism of DE is complicacy, research proof, the relationship between immunity abnormality and EE and TEN of skin inflammatio's occurrence, development becomes more and more concerned TNF-α is monocyte factor, and primarily be produced by monocyte and macropathology; and can increase phagocytosis ability of neutroph.And increase produce of ,strengthen the ADCC function, and stimulate the cell to take off the grain with, secrete the myeloperoxidase, and cause the cells death, organize to hurt, and strengthen hypersen TNF-α play an important role in system of sitivity cytokine increscent contain. Can cause IL-1, IL-8, IL-6, IFN … etc. change of contain and cause the cytokine for network to lose the balance, and farther mak...
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