The Drug Effects Study Of SanShenZiWeiYin

Chronic atrophic gastritis (CAG) is a disease with no definite Pathogeny and pathogenesis. Now the pathogeny of CAG is thought to be connected with sorrowing immunity diet bile reflux and HP infection CAG with intestinal metaplasia (IM) dysplasia (Dys) is thought to be precancerous lesion Furthermore, CAG patients are more and more among normal group. Modern medicine often use protecting gastric mucosa, cleaning away HP increasing the motivation of stomach to cure CAG Chinese medicine has dominant pasition It is sutible for long-term using, to attan the goal of better cure. San shen Zi Wei Yin (Sshzwy) is a Compound Chinese drug mainly on curing stomach-Yin as thenia syndrome in CAG. We have cured thousands of CAG patieats with sshzwy and made remarkable efficiency in clinical case. Its effective ratio achieve more than 96%. The experimental Study of SShzwy on drug effects.Resisting flame relieving pain,rejiecting diarrhea. At the same time, we design relieving pain experiment which cause the mice twist by chemistry material. Separate them to 5 groups: blank group, SASP group, great dose group, middle dose group, small dose group, and administrate them for 7 days through stomac, after that, we inject 0.7% acetic acid glacial in abdominal cavithy causing twisting stimulately, then we observe each group wether can reliev pain. we conclude that middle dose group, small dose group and SASP group can decrease the member of twisting, the drug has this function obviously (P<0.01), they tree have no difference (P>.05). Great dose group have no the function obviously. According to modern principle study of each drug in the medicine, this medicine have gray starling, licorice root, which have been proved that have no difference with Meperidine. According to above faction, we infer that the principle of that probably is to obstruct the function of reticular formation of brain stem and some descending inhibition. Method of dividing into group and administration is same to experiment of relieving pain experiment in Rejecting diarrhea experiment. We use dregs leaves making mice diarrhea, observe the information of abnomal uring. The results appear that WMS group, great dose group, middle dose group, small dose group have the function of resiste diarrhea, middle dose group, small dose group and WMS group have no difference (P>0.05), while the function of great dose group is lower than other tree (P<0.05). According to time, the difference of diarrhea number in 2 hours after serving drugs appear that small dose group and blank group have obvious difference, which prove small dose of the medicine has great and smark function, and this function has no positive correlation with dosel. Analyze the medicine, we find the function relevant with the restraining bowdls muscle of membranous milkvetch root and officinal magnolia bark. But single drug of medicinge will not appears the same function as mixed medicine. So there are a lot of things waiting to do about the function of strengthening and resisting among each other.