β-Fibrinogen Gene-148C/T Polymorphism And Plasma Fibrinogen Levels In Young Adults With Ischemic Stroke

Objective The notion that fibrinogen is related to cardiovascular disease was widely accepted. However, whether -148C/T polymorphism of P-fibrinogen gene is related to plasma fibrinogen levels and ischemic stroke is unknown. The aim of this study is to investigate the association between -148C/T polymorphism of P-fibrinogen gene and plasma fibrinogen levels in young adults with ischemic stroke.Methods 69 young patients with ischemic stroke and 60 young healthy individuals were enrolled in this trial. The P-fibrinogen gene -148C/T polymorphism was analyzed by PCR-RFLP, and plasma fibrinogen levels were obtained from prothrombin time assay.Results Plasma fibrinogen levels of patients are significant higher than those of controls (p<0.01). In both groups those with T allele have higher plasma fibrinogen levels than those without (p<0.01), but there is no significant difference in T allele frequencies between patients and controls (p>0.05). Among the smoking patients those with T allele have higher plasma fibrinogen levels than those without (p<0.05), while the difference is not significant as to the nonsmoking ones.Conclusion High plasma fibrinogen level is a risk factor for ischemic stroke in Chinese young adults. Plasma fibrinogen level is affected by -148C/T polymorphism of P-fibrinogen gene. With other risk factors and environmental factors affecting, T allele increases plasma fibrinogen level and may be a heritable risk factor for ischemic stroke in Chinese young adults.