Experimental Study On The Efficacy Of Aminophylline In The Treatment Of Cardiac Arrest

Part I: Objective To compare the efficacy of aminophylline vs. epinephrine in treatment of a rat model of asphyxial cardiac arrest. Methods Asphyxial cardiac arrest was induced by clamp the endotracheal tube. After 8 min of cardiac arrest, a bolus dose of either 10mg/kg aminophylline (n=T2), 0.02mg/kg epinephrine (n=12), or 0.3ml saline (n=12) was administered in a randomized manner. Results There were 7 rats (58.3%) return cardiac electrical activity in aminophylline group, which was no statistically difference with epinephrine group (41.7%, 5/12; P=0.684). Initiation time of resuscitation in aminophylline group was (39 23) s, which was significant quicker than epinephrine group [(90 + 42) s, P=0.021)]. There were 5 (41.7%) rats return of spontaneous circulation in aminophylline group and 6 rats (50%) in epinephrine group (P=0.000). The mean arterial pressure in 1-5 min after drug administration was (30.3 10.2) mmHg in epinephrine group, which was significantly higher than aminophylline group [(15.0 + 2.4) mmHg, P=0.043]. The mean arterial pressure in 6-10 min was (23.3 2.3) mmHg in epinephrine group, which was no statistically difference with aminophylline group [(22.7 + 2.2) mmHg, P=0.677]. The Ih survival rate in aminophylline and epinephrine group was 16.7%, which was higher than placebo group (0%,P=0.478). At autopsy the cardiac consistency score in epinephrine group was 2.5 0.5, which was higher than those in placebo group (1.6 + 0.4, P=0.007) and aminophylline group (2.0 0.5, P=0.068). Conclusion These results suggest that aminophylline could improve the cardiac electrical activity and spontaneous circulation in the rat model of asphyxial cardiac arrest, which was no significant difference with epinephrine. Initiation time to return cardiac electrical activity after aminophylline injection was significant quicker than epinephrine and the cardiac consistency score with aminophylline administration was less than epinephrine.Part II: Objective To compare the efficacy of aminophylline vs. epinephrine vs. the combination of aminophylline with epinephrine in a rat model of asphyxial cardiac arrest. Methods Asphyxial cardiac arrest was induced by clamp the endotracheal tube. After 8 min of cardiac arrest, a bolus dose of either lOmg/kg aminophylline (n=12), 0.02mg/kg epinephrine (n=12). or a combination of lOmg/kg aminophylline with 0.02mg/kg epinephrine (n=12) was administered in a randomized manner. Results The rates of cardiac electrical activity restoration were not statistically different between 3 groups (P=0.400). Initiation time of resuscitation was (43 34) s in aminophylline -epinephrine group and (39 23) s in aminophylline group. Either group was significantly earlier than that in epinephrine group (90 42) s (aminophylline -epinephrine vs. epinephrine, P=0.022; aminophylline vs. epinephrine, P=0.011). The rate of spontaneous circulation recovery was not statistically different between 3 groups (P=0.7\7). The mean arterial pressure in those achieving recovery of spontaneous circulation was (55.5 17.3) mmHg in aminophylline-epinephrine group, which was significantly higher than that inepinephrine group [(26.7 7.8)mmHg, P=0.000] and aminophylline group [(15.0 2.4)mmHg, P=0.000]. Ih survival rate were not statistically different between 3 groups (P=0.346). Conclusion These results suggest that the combination of aminophylline with epinephrine can improve the recovery of blood pressure in the rat model of asphyxial cardiac arrest.Part III : Objective To determine whether aminophylline with epinephrine has more beneficial effect than only epinephrine on the victims of cardiac arrest. Methods In a retrospective study on cardiac arrest, 24 patients received epinephrine and aminophylline and 30 patients received only epinephrine. Results There were 19 (79.2%) cases return cardiac electrical activity in epinephrine-aminophylline group and 16 (53.3%) cases in epinephrine group. The difference was marginally significant (.P=0.082). There were 12 cases (50.0%) return of spontaneous circulation in ep...