Expression Of STNFR₅₅ And Pathogenesis In 2-Type Diabetic Lean Group

To assay the serous level of Soluble Tumor Necrosis Factor Receptor 55 ( sT-NFR55) in the 2 - Type Diabetic Lean Group and the obese group by ELISA, in order to investigate whether the pathogenesis of lean group in 2 - type diabetic is different from that of obese group and has its'own immune inflammation mechanism through the correlation analysis between the serous level of sTNFR55 in the two groups and GAD - Ab.MethodsI . Serum sTNFR55 MensurationMensurate sTNFR55 by EOS A. 22 cases out of 40 clinic 2 - type diabetics belong to lean group which BMI < 21, and 26 cases belong to obese group which BMI>26.II . GAD - Ab MensurationRoot in qualitative analysis of clinic incretion laboratory.M. Statistic DispositionQualitative analysis denotes GAD - Ab and the average ?standard deviation (x s) denotes data else. Group compare is by t - test and the two variables are by x2 - test.ResultsI . The serum sTNFR55 level of the two groups of 2 - type diabetics: 22 cases of lean group are 2.916 0. 825 and 18 cases of obese group are 2.451 0.427. The serum sTNFR55 level of lean group is obviously higher than that of obese group, which has statistic significance (p <0.05). The C peptide level of lean group (493. 63 52. 05 nMol/L) is obviously lower than that of obese group (582.37 97.20 nMol/L) , which also has statistic significance (p <0. 05).II . There are 4 cases ( absorbencies are 2. 525, 2. 550, 2. 572, 2. 497, respectively ) that sTNFR55 of lean group are obviously a great distance off standard curve, in which 2 cases, GAD - Ab are positive and each occupies 18% and 9% of lean group. The two methods are interrelated by compared with the two variables, which are both strongly relative to lean group.Conclusion2 - type diabetes mellitus is a kind of heterogeneity disease. Immune factors influence the pathogenesis in 2 - type diabetes, mainly in the lean group. Maybe there are independent immune factors that are different from the obese group. It is necessary for clinic to check the level of the serum sTNFR55 and the GAD - Ab in order to analyze the pathogeny and comprehend the immune status of 2 - type diabetic lean group, as provide the study of 2 - type diabetes with indirection on methodology.