Development Of Biodegradable GTR Barrier And Its Peformance Research

Nowadays, people pay more and more attention on tissue engineering, which combines cell biology, engineering, material science and clinical medicine, etc. Textile also has new development on it. This paper mainly discusses Guided Tissue Regeneration (GTR) and "GTR Barrier". "GTR Barrier" is a kind of apparatus that can guide the regeneration of tissue, which is made of biodegradable material. At present, most researches on it are focusing on its degradation properties in vivo and in vitro, but they don't relate to the change of the physical properties during the degradation. In addition, few researches are on how materials and techniques influence the physical properties and degradation properties of GTR Barrier, so this paper will do some work on it.In this paper, the influences of materials, yarn thickness, knitting density and coating on physical properties of GTR Barrier were studied. In addition, some elementary researches were taken on several degradation properties such as strength attenuation and mass loss of different materials in vitro.Two biodegradable materials (PGLA, PGA) were selected to knit single jersey fabrics with different density as skeletons of GTR Barriers. Orthogonal test was used to select optimum parameters of material, knitting density and coating by testing splitting strength, tensile strength and initial modulus of GTR Barriers. Through the test, the comparatively better technical parameters could be found.On the base of orthogonal test, two kinds of GTR Barriers of different materials were picked out to take degradation experiment in vitro. ' Comparing the ratio of strength attenuation and mass loss of these GTR Barriers and their appearance change in course of degradation to analyze their structure characters and degradation properties. Through the comparison, appropriate material used in GTR Barrier could be selected.Through the .researches, finding a new study direction on GTR Barrier. The result of orthogonal test shows the material, knitting density of skeletonfabric and coating can remarkably influence the mechanical properties of GTR Barrier. In addition, the interaction between material and knitting density can also influence the result. The degradation courses of PGA and PGLA GTR Barriers in vitro are chemical degradation processes, which achieved by hydrolysis of ester bond. The attenuation of tensile strength is faster than mass loss. The degradation velocity of PGA film is uniform, but when it comes to PGLA film, there is a break point in attenuation of tensile strength and initial modulus during the degradation.In orthogonal test, the better GTR Barrier is 4# sample, which skeleton fabric is tightly knitted with 14tex PGLA, coated with 3.5% chitosan. The in vitro degradation experiment of PGA film and PGLA film shows that the attenuation of tensile strength and initial modulus of PGLA barrier is slower than that of PGA barrier, but its mass loss period is shorter. Judging from the appearance change during degradation, PGLA barrier has a better appearance retention than PGA barrier.