| PURPOSE: To establish limitied retinal translocation model in rabbit eyes, observe the effect of the surgery and report the histopathologic findings in the retina after surgery. METHODS: 35 pigmented rabbits were devided into 2 groups, control group (5 rabbits, 10 eyes) and experimental group (30 rabbits, 60 eyes), experimental group contained 2 subgroups: retinal detachment subgroup in left eyes and limited retinal translocation (LRT) subgroup in right eyes. Retina detachment subgroup underwent artifical retinal detachment surgery only. Limited retinal translocation (LRT) subgroup underwent artifical retinal detachment surgery with longitudinal scleral resection and scleral imbrication. The eyes were enucleated at different time (1, 2, 3,4 and 8 weeks) after operation and observed the change of retinal structure by light and transmission electron microscopy. RESULTS: One day after operation, 29 eyes (29/30) retinal reattachment except vitreous hammerage in 1 eye (1/30) in retinal detachment subgroup, and nofold in the retina; In limited retinal translocation subgroup, retinal reattachment was observed in 24 eyes (24/30), retinal translocation was achieved in 16 eyes (16/24), surgical complication occurred in 6 eyes including vitreous hammerage in 4 eyes (4/30), proliferative vitreoretinopathy (PVR) in 1 eye (1/30), huge retinal tear and redetachment in 1 eye(l/30), crista caused by scleral infolding and curvature of myelinated nerve fiber and retina vessels were seen in the eyes with successful retina translocation, and there were lot's of little folds in translocated retina Retinal histopathologic changes of two subgroup were found on the out layer of the translocated retina, including a minimal decrease in the number of photoreceptors, some degree of derangement of vertical alignment of photoreceptors and little change of retinal pigment epitheliums (RPE). Retinal structure changes could be recovered 3 weeks after operation observed by light microscopy and 8 weeks by transmission electron microscopy. Histopathologic changes were almost same between two subgroups but the polarity changes of the photorecepter outer segments in limited retinal translocation subgroup. CONCLUSIONS: Limited retinal translocation (LRT)with longitudinal scleral imbrication is an effective but difficulty technique to achieve retina translocation. Minimal changes in the photoreceptors and retinal pigment epitheliums are observed after operation and histopathologic changes of translocated retina were almost same as that of retinal detachment.
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