Effects Of Total Flavonoids Of Litsea Coreana Level On Nonalcoholic Steatohepatitis And Its Partly Mechanisms Of Action

To explore the effects of TFLC on nonalcoholic steatohepatitis(NASH), NASH model was adopted by fat emulsion.The mechanisms of action of TFLC on NASH by using the methods in vivo and in vitro at body,cellular levels were studied.The main contents are divided into some sections as follows: 1.To establish the NASH animal modelThe serum and hepatic TG increased markedly by fat emulsion in rats,and the histopathology research showed hepatocellular macrovesicular steatosis .The results indicated the experimental animal NASH in rats were successfully established . 2.To research preventive effects of TFLC on NASH.The rats were fed with fat emulsion and TFLC at the same time.TFLC markedly reduced the elevated level of serum and liver tissue TGLiver histopathological examination showed TFLC could ameliorate hepatocellular macrovesicular steatosis.The protective and therapeutic action of TFLC on NASH would be associated with inhibitory effect of fat absorption in the digestive tract and lipid peroxidition.3.To research therapeutic effects of TFLC on NASH, and its partly mechanisms of actionThe rats were first fed with fat emulsion for 3 weeks .Added to drugs by in vivo and in ivtro,TPLC markedly reduced the elevated TG level of serum ,liver tissue and HC.Liver histopathological examination showed TFLC could ameliorate hepatocellular macrovesicular steatosis.The therapeutic action of TFLC on NASH would be associated with reduction of FFA,TNF- a and lipid peroxidition.