Expression And Significance Of GST-Pi,AR In Prostate Cancer

Prostate cancer is the common malignant tumor in American and European men. Some researches have demonstrated that prostate cancer is the most common tumor in American men. It is the first leading cause of cancer death in the North American and the west Europe. The incidence of prostate cancer increased year by year in our country. Presently the sensitive andreliable early diagnosis and prevention are in need. We detected the expressions of GSTPi and androgen reciptor in prostate cancer and BPH by immunohistochemical method and discussed the relationship between the significance of the expression and the originator and development of prostate cancer. Purpose: To study the expression and significance of GSTPi androgen reciptor ( AR) in prostate cancer.MethodsImmunohistochemical method was used to detect GSTPi androgen reciptor ( AR) in 20 cases of prostate cancer and 20 cases BPH.ResultsThe expressions of GSTPi in the prostate cancer does not relate to the tumor grading and staying. The expressions of AR relates to the extent of prostate cancer , but it dose not relate to the invasion and metastasis of prostate cancer. The expressions of GSTPi dose not relate to that of AR in prostate cancer.ConclusionOne The expressions of GSTPi in prostate cancer decline more than that in that in the BPH and does not relate to the tumor grading and staying. Two The expressions of AR relates to the extent of prostate cancer , but it dose not relate to the invasion and metastasis of prostate cancer . ( Accompanying with the tumor grading becoming higher, the expression declines,but it dose not relate to the tumor staying. ) Three The expressions of GSTPi dose not relate to that of AR in prostate cancer. Four The expression of GSTPi dose not relate to the PSA level in prostate cancer , the expression of AR increases in prostate cancer.