The Study Of Serum Calcium Ion In Type 2 Diabetic Patients With Peripheral Neuropathy

Objective and Backgroud:Type 2 diabetes niellitus is becoming one of the major threatening diseases in the modern society with increasing morbidity in recent years. Diabetic neuropathy is one of the serious and main complications of diabetes mellitus. Calcium ion (Ca2+) is one of the most important ions in maintain normal activity of cells. It has been reported that Ca2+ of intraneurocyte in diabetic rats with neuropathy was increased and diabetic patients with neuropathy had significantly lower levels of serum Ca2+ compared to controls and to diabetic patients without neuropathy. In this study, we measuredthe serum Ca2+ in type 2 diabetic patients with peripheral neuropathy and without peripheral neuropathy to investigate the relationship beteewn serum Ca2+ and diabetic peripheral neuropathy.Design and methods:A total of 101 patients with type 2 diabetes , as defined by the WHO criteria, were studied. All patients were treated by diet and oral agents(and/or insulin). 31 healthy subjects were included as control. All patients were divided into two groups based on nerve conduction velocity (NCV).1. Detection of NCV: Median nerve and common peroneal nerve were detected by electrophysiological test to get the motor nerve conduction velocity (MCV); median nerve, ulnar nerve, sural nerve were detected by electrophysiological test to get the sensory nerve conduction velocity (SCV). The patients were divided into two groups: diabetes with peripheral neuropathy (NCV