| Purpose: The benign strictures of bile ducts are usually caused by the bile duct calculus, cholangitis and the iatrogenic damage of the bile ducts during surgery . The doctors both at home and abroad always adopt cholangiojejunostomy to treat the huge defect of the bile ducts. Although this kind of method does work in some scale, the reflux cholangitis usually occurs some times after the operation. In order to seek some kind of configuration that could take place the function of the Oddi sphincter to prevent the liquid reflux from duodenal to the bile duct, we performed gastroantrium-cholecystostomy, and to see whether we can use pylorus sphincter to prevent the reflux from duodenal to the bile duct. Method: We selected 15 prairie dogs(bought from the Animal Experiment Center of Sichuan University ), and were divided into three groups: the first was control group. The dogs in this group were performed the laparotomy only. The second was experimental group one that was performed gastroantrium-cholecystostomy and gastrojejunostomy. Meanwhile, weplaced two thin tubes in stomach antrium and duodenum separately for photography after operation. One week after operation, we collected the plasma of the experimental dogs and the samples of liver , stomach, stomach antrium, gallbladder and extra hepatic duct for pathologic exams. The Gn, SS, NT and -EP of plasma were examed by radiation immunity methods. 20% cyctografin( 10ml) was injected into duodenum though the two tube which was insected into duodenum during the last operation ,and to check whether or not there any backflow from duodenum to the bile duct .Then , 20% cyctografin(5ml) was injected into stomach antrium to see how it went into duodenum from stomach antrium.The last group was experimental group two . Four weeks late after operation ,the whole samples were collected as same as experimental group one.Results : The radiography showed : there was no contrast medium backflowing into the stomach antrium, and it could enter into duodenum from stomach antrium smoothly. The fixed quantifying showed : there was no significant difference of intestinal hormones in plasma among each group before and after operations(P>0.05). And also there was no significant differences between the control group and experimental groups(P>0.05). The results of pathology showed that there were no obviously changes in the liver, stomach antrium and bile duct . Only a few inflammatory cells could be founded in the gallbladder wall. The mucosa of stomach showed a slightly atrophy.Conclusion: 1. Gastroantrium-cholecystostomy which pylorus sphincter takes places the functions of Oddi sphincter, can prevent intestinal juice reflux into the bile duct. 2. There is not obvious changes betweenGastrointestinal tract Hormones in plasma before and after the operation. 3. Only slightly histological changes of the liver, the stomach antrium and the bile duct could be seen one month later after the operation. We can get the conclution : if it is necessary to do the cholangiojejunostomy, gastoantrium-cholecystostomy is a relatively better choice , because it will never damage the inner environment of the intestines, and the pylorus sphincter remains an upstanding open and close functions. It can keep back the reflux of the intestinal contents from duodenum to bile duct, which offers an alternative way for cholangiojejunostomy.
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