Animal Experimental Study On The Guided Reconstruction Of Soft Tissue Defects In The Palates Of Goats With N-HA/PA66 Plates

Objective: Different surgical flap techniques are applied to reconstruct the palatal defects caused by cleft palate or trauma in clinics. The flap techniques have some deficiencies. In this study the n-HA/PA66 plates are implanted into the defect area to close the bone defects and to guide the regeneration of mucoperiosteal tissue in the goat palates. This study is to evaluate the use of n-HA/PA66 plate as guide to regeneration of the mucoperiosteal tissue, and to provide the basis for the further study of guided bone regeneration.Methods and Materials: n-HA/PA66 was made into 1.00mm thick plates. 12 goats as experimental animals were divided into experimental group and control group (6 animals in each) at random. 18.0 × 14.0mm2 rectangle mucoperiosteum and 15.0 × 13.0mm2 rectangle bone were removed in mid part of hard palates. N-HA/PA66 plates were implanted into the experimental group defects. The same size tissues in the control group were removed without the n-HA/PA66 plate implanted. The tissue regeneration in the defects was observed and the structure of regenerating tissue was analyzed by histology.Results: The mucoperiosteal tissue in experimental group regenerated alongthe n-HA/PA66 plates and the mucoperiosteal defects were closed in 6 weeks. The n-HA/PA66 plates combined with the soft and hard tissues tightly. The soft and hard tissue did not close up in control group in 6 weeks. The structure of regenerating tissue was similar with the normal mucosa tissue. No obvious rejection reaction could be observed.Conclusion: N-HA/PA66 plates can guide the regeneration of mucoperiosteal tissue to close the palatal defect , and have the clinical application value.