| Objective After 1950s,with the rapid development of people's living conditions and changes of living habits, cerebrovascular diseases have become one of the three leading death diseases that severely threaten human health in the world. According to the statistics of WHO cerebovascular disease association in 57 countries, cerebrovascular disease ranked the first three leading death diseases in 40 countries, which is 11.3% of the 57 countries whose death number were caused by cerebrovascular diseases. Cerebrovascular disease with high death rate and mutilation rate has brought high burden to the society, family and economy. There are more than 1.5 million new stroke patients each year in our country, we have totally 6 million stroke patients at present, 75% of which have lost their work ability, 40% of which were severe disabled. It is the primary reason for disability and cognition disturbance of elderly people in our country, which has caused millions of economic losses directly or indirectly. With the increasing aging in the world and our country, this problem has becoming more and more prominent. Many clinical practices indicated that no matter what perfect treatment we have, we can not have an ideal result on its fatality rate and prognosis. Therefore the prevention of stroke has become an important task of health work, getting more and more attention by the medical field especially the neuroscince field home and abroad. In order to realize the "everyone has health in the 21th centry", the WHO bring forward and advocate the first degree prevention policy of cardiovascular and cerebrovascular diseases. However finding out and making certain the risk factors of cerebrovascular diseases, and trying to reduce or get rid of these risk factors is the basic way to preventstroke and the major public method to decrease its incidence and death rate. At present, it is known that the risk factors of cerebrovascular disease are the hypertension, coronary heart disease, diabetes mellitus, transient ischemic attack(TIA), et al., but the question arises regarding why patients with risk factors that predispose them to stroke suffer from cerebrovascular ischemia at a particular time, the risk factors may have been unchanged for a long period of time before causing a cerebral infarct. It is indicated that there maybe some unknown factors that were not realized by us. Previous infection is discussed as a risk factor for stoke abroad. But little has been reported in China. We are short of large sample and systemic studies in this respect. We performed a retrospective case-control study to make sure that the recent infection is the independent risk factor of ischemic stroke and investigated which infections are mainly relevant to the cerebrovascular ischemia in this respect.Methods we performed a retrospective case-control study with 656 patients(male 369; female 287)aged 18 to 80 years(average age 66.3 + 9.3 years) with acute cerebrovascular ischemia and 656 randomly selected control subjects matched for sex, age and nation. The patients and control subjects are the hospitalized patients of Dalian. Municipal Central Hospital from 1998 to 2000. The control cases are nonstroke patients. We recorded their predisposed risk factors which included hypertension, diabetes mellitus, coronary heart disease, transient ischemic attack, cardiac fibrillation, current smoking, intake of alcohol, hyperlipemia, family stroke history. We analysed and compared the onset time of infection, the kind of infection, predisposed risk factors in both groups. We used the statistical software package SPSS 10.0 for the analysis. We use X2 test to analyse the data. Odds ratio (OR) estimates and 95% confidence intervals (CI) are given in all analyses. We also performed a grouped nonconditional Logistic regression.Results Infection within 1 week before ictus was significant more common among patients(112 of 656) than control subjects(32 of 656; odds ration[OR], 4.0, 95% confidence interval [CI],2.7 to 6.0). infection within 4 weeks and 2-4 weeks bef...
|
PDF Full Text Request