| Objective: To characterize the injurious effects lysolecithin on the esophagus mucosa in Sprague-Dawley rats and to evaluate the preventive effects of Hydrotalcid or Sucralfate. Method: The morphology of the esophageal mucosa damage induced by lysolecithin was investigated in a experimental model,where an isolated segment of rat esophagus was perfused in situ with lysolecithin,alone or in combination with HCL. We observe the morphological alteration in light microiscopy as well as electron scanning microscopy,and calculate the damage exponent .And by establishing prevention models of lysolecithin-induced esophagus mucosa injury, we observe the effects of Hydrotalciteor or Sucralfate on the damage by light microscopy and electron scanning microscopy and on the contents of TNF- alpha, IL-1beta , and IL-6 of oesophagus detected by radiommunoassay.Result: Lysolecithin alone cause slight morphological damage to the esophageal mucosa. However, when combined with HCL lysolecithin causes marked damages. In light microscopy cytoplasmic vesiculation of epithelia cells, infiltration of leucocytes, even ulcer was seen. In electron scanning microscopy, lysolecithin causes widening of intercellular spacesand detachment of superficial cells leading ultimately to disclosure of denuded submucosal collagen bundles.The damage exponent in group D was significantly higher than that in group C (P < 0.05). The damage exponent ,the contents of TNF- a ;IL-1 0 ;IL-6 in group F was significantly higher than that in group G, group H (P < 0.05). hi electron scanning microscopy, the epithelia cell from group G, group H was normal. Conclusion : (1) Lysolecithin can injury the esophageal mucosa.The combined effect of lysolecithin and acid was more damaging than that of lysolecithin alone.(2) Both Hydrotalcid and Sucralfate were effective in preventing injury of esophageal mucosa induced by lysolecithin.
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