Randomized, Double-blind, Comparative Clinical Trial On Gatifloxacin Injection Versus Levofloxacin Injection

Objective To evaluate the clinical efficacy and safety of gatifloxacin injection on moderate and severe acute respiratory and urinary infection. Method In the randomized, double-blind, comparative study, patients were randomly divided into two groups(test group and control group. Patients were respectively treated with Gatifloxacin injection and levofloxacin injection 200mg twice daily for 7-14 days. Results l)At the end of treatment ,clinical cure rate and efficacy rate of two groups were 47.22% and 86.11%, 41.67% and 80.56%. Seven days after treatment, clinical cure rate and efficacy rate of two groups were 48.57% and 88.57%, 48.48% and 93.94%. At the end of treatment ,eradication rates of two groups were 96.77% and100.0%. Seven days after treatment , eradication rates were 93.33% and 100.0%. The values of two groups has no significant differences (P>0.05). 2)Adverse drug reactions were slight to moderate. ADRs rates were 25% and 21.05%. Conclusion Gatifloxacin injection is effective for moderate and severe acute respiratory and urinary infection.