The Correlation Study On Serum Erythropoietin, Calcium Phosphate Levels In Cord Blood And Pregnant Woman Peripheral Blood

ObjectiveErythropoietin (EPO) is an important hormone in regulating erythrocytic hemopoiesis. It is essentially produced in kidney, and then liver and other tissues. EPO ,Calcium( Ca) and Phosphate(P) play important roles in fetal growth. We studied the relationship between EPO ,Ca and P to discuss their important role in neonate and pregnant woman, and direct treating pregnant anemia and postpartum anemia with EPO. And elucidate the significance of supplying Ca for pregnancy. MethodsThe gravida were divided into two groups according to hemoglobin(Hb), Red Blood Cell (RBC), hematocrit (HCT), one is anemic pregnant women, the other is normal pregnancy. The birth weight was measured and at the same time the levels of EPO in pregnant woman and umbilical cord were assayed by Radioimmunoassay (RIA). The gravida were divided into two groups according to whether or not supplementation with Ca in pregnancy, one is supplementation with Ca in pregnancy, the other is not. The levels of Ca, P were measured in pregnant woman and cord blood serum. The data were analyzed with SPSS 10.0 for Windows. ResultsThere were no significant differences in age (29.40 6.06 vs 27.69 3.21 years) , gestational age (37.87 1.60 vs 38.59 1.78 weeks) , birth weight( 3267.87 794.536 vs 3232.41 543.036 gramme) between the anemic pregnancy and normal pregnancy. The level of EPO in anemic pregnancy (32.140 21.583mu/ml) is higher than that in control ( 19.030 13.946 mu/ml) groups, But there was no difference in cord blood EPO in two groups. There was significant correlation between pregnant woman RBC count and EPO level of pregnancy (r=-0.365, P <0.05), between pregnant woman Hb, RBC, HCT and the EPO level of cord blood in control(r=0.539, P <0.01; r=0.421, P <0.05; r=0.612, P<0.01) .There were no difference in age and gestational age between the two groups of supplementation with Ca or not. The levels of pregnant Ca (2.3076 0.1717mmol/l) , P (1.3643 0.1830mmol/l) in supplementation with Ca groups are higher than those in control group (1.7390 0.7353 mmol/1; 1.1425 0.4409 mmol/1) .There were no difference in cord blood Ca, P in two groups. There was positive correlation between gestational age and pregnant Ca (r=0.369, P< 0.05) and P (r=0.390, P< 0.05) ; There was negative correlation between gestational age and cord blood Ca (r=-0.423, P< 0.05) , P (r=-0.466, P< 0.05) in supplementation with Ca.There was no correlation between level of Ca, P and EPO in gestational period. Conclusion1 .The level of EPO in anemic pregnant women is significantly higher than that in control.2. In gestational period, there was no correlation in the level of EPO between pregnant woman and neonate. So we can draw a conclusion that anemia in pregnancy can not affect the neonate.The neonate and newborn were not anemic.3. The level of Ca, P in supplementation with Ca is significantly higher than those in control, and serum Ca, P in pregnant woman can transport through placenta and meet the requirements of the fetus' growth. 4.The newborn of anemic pregnancy has no malformation.