The Expression Of Platelet-derived Growth Factor In The Interface Between The Ti6Al4V Alloy Disposed With Surface Oxidative Film And The Bone: An In Vivo Study

ObjectTo evaluate the biocompatibility of T16A14V alloy with disposed oxygenative surface film, we have detected the expression of platelet -derived growth factor ( PDGF) at the bone - to - implant contact interface.MethodWe divided 90 wister mice into 3 groups randomly, the number of male and female was identical, then we embedded the three different implant materials into mice s mandibular , and execute mice after 1, 2, 3, 4, 6weeks, then the tissue sample were fixed , dycalciumed ,HE and PDGF immunohistochemical staining, and we analyzed the average gray value of the bone - to - implant contact interface.ResultsExpressions of PDGF in each phase are different ( P < 0. 05 ) . They emerged at the 3rd day , reached peak in the second weekend and the third week and then declined in the forth week, the finding of this study indicate a significant difference of the expressions of PDGFof Ti6A14V alloy with disposed Oxygenative surface film compared with Ti6A14V alloy and stainless steel (316L) ,P <0. 05. And sex cement had nonsignificant difference .ConclusionThe biocompatibility of disposed Oxygenative surface film Ti6A14V alloy is better than Ti6A14V alloy and stainless steel obvious-ly.