The Effects Of Schisandra Fruit On The Sleep Of Freely Moving Rats

Somnia is a kind of physiological action and the most important condition of keeping health. Somnipathy is a common disease and some diseases' concomitant symptom .The chemosynthesis sedative-hypnotic is widely applied in the clinic to treat somnipathy, but those shorten SWS and REMS resulting in producing some side effects, such as dizziness, somnolence, dependence and addiction for longly taking medicine, rebounding phenomenon and abstinence for suddenly withdrawing medicine.At present, we believe researching.and developing the drug ,which can prolong SWS selectively and maintain normal proportion of REMS, will improve sleep effectively and enhance sleep quality.At first, Schisandra Fruit decoction and Schisandra Fruit ultra-powder decoction are studied by the method of prolonging sleep time of mice made by sodium pentobarbital. The results show that both Schisandra Fruit decoction and Schisandra Fruit ultra-powder decoction can increase duration of mice sleep, and Schisandra Fruit ultra-powder decoction is superiority. On the base of this experiment, we record EEG in freely moving rats for 4.5h every day. The results indicate that Schisandra Fruit decoction and Schisandra Fruit ultra-powder decoction can increase the duration of TST and SWS2, and have no effects on SWS1 and REMS.