The Study Of Brain MRI In Adult With Hypertension And Animal Model Experiment Concerned

Objective: To explore the relationship between hypertension and chronic brain damage by analysis of MRI. SD rats were reproduced hypertensive model. In order to recognize the brain chronic damage due to hypertension further, the evolution of MR imaging and pathology of the rats brain was assessed.Methods: (1) Two hundreds and thirty-seven cases of adult with hypertension and normal blood pressure were scanned by MRI in First Affiliated Hospital of Jinan University. We grouped these cases according to age and analysed their MRI findings in details. (2) 30 adult SD rats, after killed one, others were grouped normal (n=10) and hypertension (n=19) at random. Before and after operation, we measured the blood pressure of the tail artery and performed MR scan every two months. During the mean time, one rat was killed in every group. The pathological change of rats brain was observed by HE and MBP immunohistochemical staining.Results: (1) High signal intensities (HSIs) of the brain increased with age. In the basal ganglia, internal and external capsule, corona radiata, centrum semiovale, periventrical, the incidence rates of HSIs in hypertensive patients aged from 60-69 were greater than that of the group with normal blood pressure (P<0.05), which was more likely tomake the cerebral ventricle to enlarge (P<0.05). (2) In mormal group, MRI findings of rats brain were normal, and there were a little neurocyte degeneration of rats brain at the 14th and 16th month after operation. In hypertensive group, enlargement of lateral ventricle from the 8th month, The pathological changes observed in periventricular caudate putamen were degeneration of gliocyte, a little vacuolar in myelin sheath; The strip shape hyperintensity at paraventricle which was detected on the MRI was characterized by degeneration and proliferation of gliocytes, degeneration of myelin sheath.Conclusion: 60-69-year-old hypertensive patients often present brain significant damage. There are obviously pathological change and abnormal MRI finding in caudate putman only in older rats with chronic hypertension.