Relationship Between C-Reactive Protein And Type 2 Diabetes With Cariovascular Disease

OBJECTIVE To assess the association of circulating levels of high sensitivity c- reactive protein(hsCRP) and type 2 diabetes mellitus(DM) with/without cardiovascular disease. METHODS To measure the plasma levels of hsCRP by immunoturbidimetyic and interleukin-6 (IL-6) by radioimmunossay in 77 type 2 diabetic patients with or without cardiovascular disease and 30 normal controls at baseline . RESULTS (1) As compared with the controls, Baseline levels of hsCRP (P<0.01) and IL-6 (P<0.05) were significantly increased among DMcases; the plasma levels of hsCRP and IL-6 were significantly higher in DM patients with cardiovascular disease than without cardiovascular disease (P<0.01); in the patients of diabetes mellitus with myocardial infarction in the past , the plasma levels of hsCRP and IL-6 were highest. (2) Plasma hsCRP,IL-6 were positive corrections with BMI,HbA1c,HOMA-IR,TC,LDL-c,BP, and negative corrections with HDL-c; There was a positive correction between plasma hsCRP and IL-6. (3) The plasma levels of hsCRP,IL-6,TC were positive factors in the developing of diabetic cardiovascular disease, especially plasma hsCRP. CONCLUSION (1) The plasma levels of hsCRP and IL-6 may be as sensitive markers for early diagnosis of diabetic cardiovascular disease and predicting the prognosis. (2) Plasma hsCRP and IL-6 maybe relate to type 2 DM and insulin resistance. (3) Routinely measure the plasma levels of hsCRP and IL-6 in Type 2 DM can help to prevent and to intervene the developing of diabetic cardiovascular disease.