Experimental Study On Detection Of Acute Cerebral Ischemia With Multi-Slice CT Perfusion Imaging

Purpose: To investigate the ability of the four-slice perfusion maps derived by the newest multi-slice CT perfusion imaging (CTPI) to detect ischemic lesion in rabbit models with the middle cerebral artery occlusion(MC AO).Materials and Methods: Sequential dynamic CT studies were performed at four slices in 2 control rabbits and another 8 with MCAO. The volume of critically ischemic lesions on CTPI maps at lst,2nd,3rd hour after operation and the volume of infarction measured by postmortem 2,3,5-triphenyltetrazolium chloride (TTC) staining were analyzed by analysis of variance with random blocks design and linear correlation. Results: In 6 of 8 animals of the ischemia group, critically ischemia or infarction was visible on perfusion maps and TTC-staining,while appearing negative in 2 control rabbits. In four-slice CTPI maps, lesions were visualized in 2 of 4 slices at least. The results of analysis of variance demonstrated that three deal factors, time, CTPI maps, animal, had statistical significance. The intergroup differences were discovered between 1st and 2nd, 3rd hour after operation, and between MTT map and other CTPI maps (P<0.001). There was correlation between the lesion volume from CTPI maps and the infarction volume from TTC-staining. Perfusion map and MTT map had better correlation with TTC-staining (pearson R=0.94 and R=0.905) than TTP map(R=0.864) and PEI map(R=0.814). Conclusion: Multi-slice CT perfusion imaging can better detect the size and degree of earlly cerebral ischemia. And can be beneficial to interprete ischemic penembra.