| Objective: To study the clinical effect of primary hepatocarcinoma treated by interventional therapy combined with peritoneal cavity chemotherapy, and to evaluate the immunological function of patients. The side reaction of interventional therapy and peritoneal cavity chemotherapy was studied. We further evaluated the relationship between angiography, lipoidol deposition and prognosis.Methods: All the patients were confirmed to be middle and advanced primary hepatocarcinoma with clinical data, some of the patients were confirmed by biopsy or fmeneedle aspiration biopsy. All the enrolled cases had complete clinical data, iconographic data and intact laboratory examination. They all had not received radiotherapy in recent four weeks, with no major organs damaged, Kamofsky scores 60.The patients were randomly divided into control group (interventional therapy group) and study group (intervention combined with peritoneal cavity chemotherapy group). Thirty volun-teers comprised the normal control group. In the study, the changes of T lymphocytes were analysed with FCM (flow cytometry), the alternation ofserum soluble interleukin-2 receptor was measured with ELASE, and the level of serum AFP was measured with radioimmunoassay. The changes of angiography and CT image were compared before treatment and after treatment to evaluate the clinical effect of the two chemotherapies, and their side reactions were also observed.Results: 1. The T4 level and T4/T8 ratio in PHC patients were lower than those of the volunteers'. During the treatment, the T3 level didn't show obvious change. In the control group the T4 level increased slightly and T8 decreased during the first and the second course of treatment, while during the third and fourth courses of treatment, T4 slightly decreased and T8 increased. No statistical differences were found between pre-treatment and post-treatment. In the study group the T4 level increased significantly and the ratio of T4/T8 also showed significantly decrease. 2. The level of serum soluble interleukin-2 receptor of the two groups of patients was significantly higher than that of normal control group (p<0.01). It began to decrease after treatment, and reached the lowest point at two weeks of treatment. Two weeks later, the sIL-2R maintains a stable lower level in study group, while in control group it restored to the level of pretreatment. After several courses of treatment, the sIL-2R kept to a stable lower level in the study group, while in the control group the serum sIL-2R declined temporarily, and then it increased gradually. 3. The levelsof serum AFP significantly decreased in the two groups compared pre-treatment with post-treatment. The AFP level of the study group was significantly lower than that of control group (p<0.01). 4. The deposition of lipoidol was classified into four types: complete deposition, aerates deposition, defective deposition and infrequent deposition. The recurrence rate of complete deposition and areatus deposition was lower than that of defective deposition and infrequent deposition. The recurrence rate of study group was lower than that of control group. 5. There was no significant difference between the two groups in side reaction.Conclusions: 1. To PHC (primary hepatocarcinoma) patients, the interventional therapy combined with peritoneal cavity chemotherapy could more effectively enhanced the patients immunological function than the single interventional therapy, the side reaction of interventional therapy could be tolerated by patients. There was a perfect prospective for the clinical application of immunomodulator. It could accelerate the patients immunological function and improve the long-term survival rate. 2. The interventional therapy combined with peritoneal chemotherapy could control the disease progress, it was superior to the single interventional therapy in the prevention of local recurrence and distant metastasis. 3. The dynamic monitoring of serum sIL-2R combing with serum AFP, clinical and iconographic data could be regarded as a...
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