Selenium And Protection Of Myocardial Ischemia-reperfusion Injury During Heart Operation By Analysizing Mitochondria Lesion With Electron Microscope

Objective To research the relationship between trance selenium and protection of myocardial ischemia-reperfusion injury during heart operation by analysizing mitochondria lesion degree with electron microscope. Methods 31 patients sufferred to rheumatismal heart disease (RHD) were researched.All the patients with longer history than 10 years and more than one valves involved were classied randomly into group A(selenium-group supplemented) and group B(non selenium-supplemented group).The serum selenium level of the patients was examinuted for comparing to that of normal people in another group. Supplementation of selenium have been given to the patients in group A for 2 weeks. The serum selenium level was examinated again after 2 weeks of selenium supplement. Then 16 paticnts(DVR operation) are selected from all thepatients.8 from group A, the others from group B. Right artrium myocardium collected to make electron microscope samples after ischemia-reperfusion injury for 30 minute during valves replacement operation.The mitochondria lesion degree was analysized by electron microscope. Results The RHD patients1 serum selenium level was lower evidently than that of the normal (P<0. 05). But i t may reach the normal level after selenium supplement. The myocardial mitochondria lesoin afterischemia-reperfusion injury in group B was more serious than that of group A(P<0.05).Conclusion Se-supplementation to the RHD patients can highten their serum selenium level and diminish the mitochondria lesion degree. Selenium plays a important role to the protection of myocardial ischemia-reperfusion during heart operation.