The Value Of FDP Aldolase In Evaluating Of Tumorous Tissue Damage By Ablation Therapy Of Hipatocellular Carchnoma

Objection: The purpose of this study was to evaluate the value of fructose 1,6-diphosphate (FDP) aldolase in detected tumorous tissue damaged by Percutaneous Ethanol Injection(PEI) and Radio-frequency ( RF) Ablation in patients of Hepatocellular Carcinoma(HCC). Methods: 32 patients with HCC containing 38 tumor nodules were divided into two groups: PEI and RF groups. In PEI group, there werelS patients with 24 tumor nodules, and 14 patients with 14 tumor nodules were in RF group. Changes in serum levels of FDP aldolase activities were analyzed in patients with HCC treated by PEI and RF at different time. Activities of serum alanine aminotransferase(ALT) > aspartate aminotransferase(AST) and the levels of serum alpha-fetoprotein (AFP) were also measured. These indexes were compared between pre-treatment and post-treatment. In order to learn the distribution, we compared serum FDP aldolase with AFP -. AUI\ AST, respectively. Results: Serum levels of FDP aldolase in HCC were higher than the controls pre-treatment . Serum levels of FDPaldolase released by ethanol injection were increased (P < 0.05) after the first PEI and thereafter decreased just like the wave. After the eighth PEI, it came back to the levels of pre-treatment. In group RF, serum levels of FDP aldolase were increased after twenty-four hours, and then descend straightly (P < 0.05); It came back in pre-treatment after seven days. Changes in serum levels of FDP Aldolase indicated tumor tissue necrosis in HCC. Serum levels of AFP were decreased after treatment ,and there were significant different between pre- and post-treatment, it also indicating adequate tumor tissue necrosis. The difference between activitise of serum FDP aldolase and ALT\ AST were significance(P < 0.05) at each treatment. In PEI group, Serum levels of ALT> AST were elevated after repeated PEI from first to fourth time. Compared with pre-treatment, it had significantly different (P < 0.05) . After the fifth PEI, Serum levels of ALT> AST were similar to pre-treatment. In RF group , Serum levels of AUI\ AST were highest in the first day after treatment, and then they were progressive decreased in the third and fifth day, but still had signifficanl different (P < 0.05) comparing with pre-treatment. After one week, serum levels of ALT> AST were similar to levels of pre-treatment. Conclusions: Serum levels of FDP aldolase have increased significantly in HCC, it is available to diagnosis of HCC. Measurement of FDP activities in serumafter ablation treatment is clinically useful to detect the degree of tumorous tissue damage ^specially for the case that AFP is negative. Serum levels of ALT- AST can be indicated lesion degree in tissue beside the tumor. Combining with ALT\ AST, Serun levels of FDP aldolase has great value in the judgement of necrosis in tumor tissue.