Effects Of Shenmai Inject On Isolated Rat Thoracic Aorta And The Possible Mechanisms

BackgroudShenmai inject, which is made from Radix Genseng and Ophiopogonis,is developed according to a modified recipe derived from an ancient recipe "SHEN MAI SAN Power" on the basis of scientific research, pharmacological studies and clinical verification.It can replenish vital energy to arrest discharges, nourish yin to increase body fluids and restore pulse. Shenmai inject has multiple pharmacologic effects. It can countershock, antiarrhythmia, strengthen myocardiac contraction, accommodate immunity, antiinflammation, etc. In clinic, it is applied to therapy or/and prevent various kinds of shock, hypotension, arrhythmia, coronary heart disease, viral myocarditis, heart failure, chronic pulmonary heart disease, epidemic hemorrhagic fever, granulocytopenia, pneumonia and tumour, and so on. In clinic, Shenmai inject has satisfactory effect not only to therapy various kinds of shock and hypotension, but also to therapy hypertension.It has not apparently effect on normal blood pressure. These shows the function of it is to stabilize the blood pressure. Some studies show it can raise blood press at snail dosage (0. 05)2. Shenmai inject significantly inhibited the contraction of the vascular rings induced by 10~6mol/l of phenylephrine, the inhibition showed a concentration-dependent positive correlation (P<0. 01) and no difference in the inhibition between the vascular rings with and without endothelium for the same concentration of shenmai inject, (compared the vascular rings with endothelium with the vascular rings without endothelium, all P>0. 05)3. After the vascular rings without endothelium were incubated with 30ml/l of Shenmai inject for 20 min, the concentration-response curve of phenylephrine shifted to the right and the maximum response was reduced, except for the concentration of 10...