| The hepatic neoplasm is one of the most common malignant diseases in the world, which threatens the people's health and life quality seriously, Because the early symptoms of the hepatic neoplasm lack of specificity, there have been low early diagnosis rates for a long time, so when the diagnosis was confirmed ,most of cases have been developed to late stage ,accompanied with hepatocirrhosis, the hepatictomy was unable to do, also not susceptible to chemotherapy or radiotherapy, then, complex therapies are applicable, among which Transcatete Hepatic Artery Ernbolization is very effective .But liver is an organ of double 5 blood supply, we can't achieve satisfying results only by treating patients with Hepatic Artery Embolization, nowadays, people have focused on Radio-frequency Ablation by clustered electrode. However, the tumors turned to be so big and in late stage in most of patients, and the duration of this treatment is so long, that therapies are readily to be incomplete .The aim of this study is to evaluate how Transcatheter Hepatic Artery Embolization influences on Radio Frequency Ablation experimentally and clinically and to find a new approach to treat hepatic neoplasms. Materials and methods l.Animal study Twenty-four small domestic white pigs (weight l5kg± 0.6kg) were divided randomly average into two groups. In group A (12), Radio-frequency thermal ablation (RFA) of normal liver was given one week after transcatheter hepatic artery embolization (TEHA) with Iodized oil and Gelatin sponge, group B (12), RFA was given without using TEHA; in addition, six ex-vivo liver of pigs Radio-frequency thermal 6 ablation. 2. patient study Clinic patients divided into 2 groups, group C (23), in the near future detected hepatic neoplasrns, after 7-14 days transcatheter hepatic artery embolization; group D (16), didn't trenscatheter hepatic embolization, and all radi ofrequency ablation of hepatic neoplasrns. Results 1. Hepatic function change: The total protein and albumin were droped, the total bilirubi aspartate transaminase and alkaline phosphatase were heightened. This change was temporal and recovered normal in one week. 2. The time and the diameter of coagulation necrosis of RFA change: (1) The time of RFA to ex vivo liver of pigs was 6.0±1.4 minutes ,the diameter of coagulation necrosis optimal RFA was 5.5±0.7cm; (2) The time of RFA to group A was 8.0±1.3 minutes, the diameter of coagulation necrosis was 4.7±0.6cm ; the time of RFA to group B was 12.0±1 .8minutes,the diameter of coagulation necrosis was 4.0±0.9cm (p<0.01) (3) The time of RFA to group C was 9.0±2.1 minutes, the diameter of necrosis was 5.3?.4cm, the time of RFA to group D was 16.0± 4.6 minutes, the diameter of necrosis was 7 3. Pathologic change: The necrosis was downright after RFA treatment, third day the necrosis was biggest, didn't find live-cell in RFA treatment regions. Conclusion 1. Radiofrequeney liver ablation will lead to hepatic function damaged, but this was temporal and was recovered normal in one week. 2. Ra...
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