| Objective: To evaluate the role of endothelin on acute xscheniic stroke and diaschisis in rats with cerebral infarction. To study the relationship between endothelin and acute ischeniic stroke ; and whole brain blood flow, and diaschisis following MS in SD rats Materials and Methods: 42 rats were randomly divided into the control group(6 rats),the MS for 3W. 12W. id. 3d~ 7d and 14d groups(6 rats for each group) The endothehn in endothelial cells and leiomyocyte of small of cerebroartery in ACS in different stages during ACS was determined using vacuum cabinet and normal LSAB inimunohistochemical staining method Results: 1 We found that endothelin in endothelial and leiomyocyte of small cerebroartery of the whole brain is very high contrary to the control group 2 Endothelm in the ischemic was remarkably high compared to homologous contralateral area to the entire unaffected hemisphere and bilateral cerebellar hemisphere in infarction lateral cerebroartery The difference was statistically significant (pO.05); the difference between contralateral and bilateral cerebellar hemisphere with the control group was statistically significant (p |
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