Protective Effects Of Panax Notoginseng And Astragalus Membranaceus On Multiple Organ Damage During Intestinal Ischemia Reperfusion In Rats

To investigate the protection of panax notoginseng and astragalus membranaceus (AM) during intestinal ischemia reperfusion injury (I/R) and to examine the mechanism by which the multiple organ was damaged. Intestinal ischemia reperfusion model in rats was induced by clamping superior mesenteric artery for 60 minutes period and then releasing the arterial clamp. Total Saponins of Panax Notoginseng (PNS) or AM was administered intravenously 30 min before reperfusion. Compared with control groups after 6 hour reperfusion, the biochemistry changes indicated that function of liver and kidney was damaged, the level of MDA was gradually increased, while the activities of SOD was gradually decreased, the level of TNF increase rapidly after release the clamp. Furthermore, the results showed that pretreatment with PNS or AM significantly lowered the level of MDA, the plasma TNF content, improved the activity of SOD and notably improved the function of organs. This study demonstrated that intestinal ischemia reperfusion may result in multiple organ failure, the machanism may be involved in bacterial translocation which in turn activates macrophages that leads to systemic inflammatory response syndrome (SIRS) and release of reactive oxygen species. PNS and AM can protect organs against I/R.