Study Of Suppressor Oncogene Pten/mmac1/tep1 Protein Expression In Colorectal Adenoma And Carcinoma

Objective:To evaluate the relationship of PTEN/MMAC I /TEPI expression and colorectal adenoma and carcinoma Methods: Expressi ons of PTEN are determined in 23 cases of human normal large intestinal mucosa and 28 cases colorectal adnoma and 75 cases colorectal carcinoma by immunohistochemical S-P techinque. Results: The positive expression rates of PTEN in nomal large intestinal mucosa and colorectal adnoma are 91 .3%(21/23) and 89.3% (25/28)respectively (P>0.l),while the positive rate of the carcinoma is 68%(52/75), in contrast with the two groups afore, the difference is significant(P<0.0 1 ).The positive rates in group with lymph node metastases and without lymph node metastases are 43%(12/28) and 83%(39/47), the difference is significiant(P<0.01). The positive rates in groups with distant organs metastases and without distant organs metastases are 43.5%(1O/23) and 78.8%(41/52) (P