Optimization Of The Extraction Of Erythromycin Thiocyanate And Technique Of Reusing The Mother Liquid

In this paper, study on the low yield problem in which erythromycin thiocyanate product process. Which applied the PX—90 separator and demulsifier X in the actual extraction production of erythromycin thiocyanate.Optimization of the technique to extract the erythromycin thiocyanate and setting the new production process.The process being as following:about 30℃, controlling pH>10.0, n-butyl acetate : filter liquid = 0.12～0.17. When crystallization is being,firstly, adding 15% NaSCN by the ratio of 1.3～1.5L/BU(one billion unit of the extraction liquid ).Secondly, adding 15%(v/v) HAc by the ratio of 0.4L/ BU. Thirdly, monitoring pH and controlling the end pH ranges from 6.3 to 6.5.Erythromycin thiocyanate and erythromycin of alkalization-crystallization of erythromycin thiocyanate are all qualified with the CPV2005 and CP2005 by this way.Weigh yield of alkalization-crystallization of erythromycin thiocyanate improve 2%--3% than the old technique. It is 62～63%.In the same time, using the stirring model: curved leaves of the disc turbine type agitator in the bottom of the pot ;bended leaves of paddle type agitator in the middle of it and three flaps on the wall of it. Study on the stirring model of erythromycin thiocyanate crystallization .Setting a technique which using the mother liquid of alkalization of erythromycin thiocyanate products erythromycin thiocyanate. Solving the scale of the pot and unaccepted product.