Synthesis And Insecticidal Activity Of The Hepthydroxy-β-dihydroagarofuran Derivatives

In order to study the relationship between the structure and insecticidal activity ofβ-dihydroagarofuran compounds, 1β, 2β, 4α, 6α, 8β, 9α,12-hepthydroxy-β-dihydroagarofuran polyol—the basic hydrolysis of the extract of the root bark of Celastrus angulatus Max. was modified to 1β, 2β, 4α, 6α, 8β, 9α,12-hepthydroxy-β-dihydroagarofuran, then esterified and etherified. Most of the compounds were evaluated on their insecticidal activity and antifeedant activity and their structures were elucidated mainly based on NMR and MS spectral datas.Eleven ether derivatives ( 5.1-5.11 ) and three ester derivatives(5.12-5.14) were synthesized, their structures were elucidated mainly based on NMR, and MS spectral datas. Bioassay results indicate that they exhibited some degree stomach toxicity and antifeedant activity against the third instar larvae of Mythimna separata at the concentration of 20 mg·mL-1,some of the compounds exhibited some degree activity against the third instar larvae ofAedes albopictus at the concentration of 150 mg·mL-1.These results are useful for the future research about celangulins.