Preparation Of Xianglian Dropping Pills And Its Curative Effect On Ulcerative Colitis In Mice

Xiang Lian Wan is a classical and efficient formula specified for diarrhoea and dysentery.It was first presented in"Bing Bu Shou Ji Fang".It has the effects of clearing away heatness and relieving dampness,heat dysentery,some pills,tablets and other formulations in Clinical use.According to effective chemical composition and characteristics of the dropping pills,Xiangliang pills will be improved droping pills.Even on the preparation of dropping pills,study on quality standards,free drinking DSS mice model of ulcerative colitis,and dropping pills treatment mice trial,the preliminary study about therapeutic effect.The composition of huanglian and muxiang.In the extraction of raw materials in medicine,In this paper,single-factor orthogonal experimental design and study a combination of filtering out the best extraction process,retained the prescription of wood essential oil,the effective parts group: Berberine,volatile oil and wood total alkaloids,and were used by HPLC and TLC method has its quality control in preparation molding,the paper used solid dispersion techniques to PEG4000: PEG6000(1:1)as a matrix,Methylsilicone oil as a condensation of the dropping pills process optimization.Which have a High yield dropping pill.And the "Chinese Pharmacopoeia"(2005 version)in Appendix IK dropping pills under the relevant provisions.In quality control:TLC qualitative research,using UV and HPLC quantitative research,the preparation of the content of berberine,the method of inspection.The results showed that:the advanced process dropping pills,the appearance of characters,and pills weight differences was small,samples berberine content of 0.372%(mg/g),volatile oil than the total 0.10%(mL/g),The average recovery rate was 103.16%, RSD%was1.01 percent.dropping pills with the quality standards.Establish the dropping pills' draft of the quality standards.The study of production and provide scientific basis for the preparation of pharmaceutical raw materials and laid the foundation for Standardization,the process for the Modernization of Traditional Chinese Medicine to provide the feasibility.At treatment of ulcerative colitis in mice,BALB/c mice are targeted by DSS drinking water for free.DAI,pathological changes in morphological,biochemical indicators identified show success.In the treatment effect on the DAI,pathological changes in morphological,biochemical indicators for analysis.The results showed that:the use of high-dose group of agents to the DSS model for the treatment of ulcerative colitis in mice,compared with the model group DAI scores decreased significantly(P＜0.01),colon mucosa injury reduced significantly,SOD activity increased,MDA content A significant reduction,provide reference for clinical research..