Study On Expressive Regulation Of The E3 Region Of Canine Adenovirus Type 2 And A Recombinant Vaccine Carrying Rabies Virus CVS Glycoprotein

Rabies is a zoonotic disease that causes severe destruction to the central nervous system and is usually fatal. In recent years, China has reported the second highest rates of illness and death from human rabies worldwide. The domestic dog plays a pivotal role in rabies transmission; 85–95% of human rabies cases are ascribed to dog bites, and 50–70% of human rabies cases are reported in rural areas. Low vaccination coverage of dogs and wildlifes is widespread, largely because of poor awareness of rabies and the high cost of vaccination.Dogs and wildlifes of canis familiaris are the main transmission intermediary of rabies, so the control and eradication of human rabies depends on the development of safe, effective and economical vaccine that might be used in preexposure vaccination programs for animals. A recombinant canine adenovirus type-2 expressing the rabies virus low virulent strain SRV9 glycoprotein has been constructed by our lab in previous, meanwhile the immunogenic effectiveness of rabies was showed effective, but it was still lower compared with immunization with live or inactive rabies virus. The immunogenic effectiveness of recombinant vaccine might be effected by many factors, such as selection of protective antigen, levels of the transgene product, the levels of preexisting immunity...