Effects Of Castor Bean Extract On Antifertility In Mice

Antifertility drug on mice is the medicine aiming at decreasing the birth rate of various murid, including contraceptive agent, ovicide, feticide and spermicide. In details, it reacts with the effects on reproduction so as to prevent pregnancy one-way or bilaterally in short term or long term. In this way progeny size and generation are controlled effectively. At present, main antifertility drugs are chemosterilant, biosterilant botansterilant and so on. As more attach was paid to environment protection and the rise of difficulty of chemosterilant exploitation, sterilants extracted from plants has been the new highlight of exploitation. Castor bean extract and the contraceptive proteinum can be made as sterilants or lead compound to exploit biosterilant since they are extracted directly from natural plants, and biodegradable with little pollution to enviroment.Castor bean extract and contraceptive proteinum have apparent effects of antifertility on mice. Proteinum and the mixture of proteinum and castor bean extract respectively can show 100% antiearly pregnancy in multiplication experiments, while castor bean extract can show 100% anti-implantation. In long term antifertility, castor bean extract is of good effect which can decrease mice's production and generations within 210 days(about 10 generations),and the fertility inhibition ratio will above 80% when the dose is 325mg/kg. Besides, significant effects are found in mice's isolated uterus by castor bean extract and proteinum, which decreased the probability of nidation in the way of strengthening the contraction in uterus. In the experiment of fetation interception, no nidation site was found after the administration of contraceptive proteinum and the mixture of proteinum and castor bean extract.