Infection / Colonization Monitoring And Risk Factors Analysis Of Candida Oralis In Hospitalized Patients During Dermatology

Objective To study oral candidasis and colonization situation and risk factors of inpatients in the department of dermatology, to provide the guidance about oral candidasis diagnosis and therapy of inpatients in the department of dermatology.Methods To do oral fungal microscopy and culture of dermatology inpatients at the first Affiliated Hospital of Kunming Medical University from January 2009 to December 2013,and use a pre-designed questionnaire to record relevant clinical data, and statistical analysis.Results 1. Monitoring dermatology inpatients 4192 cases from 2009 to 2013, that oral Candida infections in 61 cases(1.46%), oral Candida colonization cases of 529 cases(12.62%).2. The infection group, male to female ratio of 1.03:1; the colonization group, male to female ratio was 1:0.88, the gender distribution of the two groups were not statistically different (χ2=0.340, P=0.560).3. The average age of patients infected with 50.03±21.69 years, the average age of patients colonized 54.51±20.41 years, the average age was no significant difference between the two groups(t=-1.613, P=0.107).4. The infection groups is mainly distributed in pemphigus, drug eruption, SLE, bullous pemphigoid several diseases, accounting for 31.15%,16.39%,14.75%,13.11% of infection cases; the colonization group with herpes zoster, eczema, hives, psoriasis,accounting for 23.25%,16.64%,8.32%,6.24% of colonization cases.5. The average hospital stay of the infection groups is 17.52±7.55 days, and the colonization group is 9.99±3.95 days(t=7.672, P=0.000), the former group is significantly longer than the latter.6. At the infection groups, corticosteroids, antibiotics and immunosuppressive agents utilization rates is respective 91.80%,52.46% and 29.51%,and the colonization group is 52.74%, 26.84% and 1.89%, their usage rates of the infection group was significantly higher than the colonization group (P<0.05).7.598 strains of candida were separated from patients’ oral of the infection group and the colonization group. Among them, Candida albicans are 492, accounting for 82.27%; non-Candida albicans are 106, accounting for 17.73%.8. Multivariate logistic regression analysis showed that:hospital stay, use of hormones, the days of using hormones, use of antibiotics, use of immunosup-pressive agents are major risk factors of Oral Candidasis.Conclusion 1. Oral Candidasis and colonization of Dermatology inpatient are significantly lower than the overall level of the hospital.2. The vulnerable population of Oral Candidasis are Pemphigus, Drug eruption, SLE and Bullous pemphigoid in the department of dermatology, and oral Candida colonization with shingles, eczema, hives, psoriasis Patients were more common.3. The long hospital stay, use of corticosteroids hormones, antibiotics and immunosuppressive agents and prolonged use of corticosteroids are major risk factors of oral Candidasis.4. The main candida species of oral Candidasis/colonization is still Candida albicans from our hospital dermatology inpatients.