Design, Synthesis And Bioactivity Of Imidazole Derivatives

Imidazole ring is an important five-membered aromatic heterocycle widely present in natural products and synthetic molecules. The unique structural feature of imidazole ring with desirable electronrich characteristic is beneficial for imidazole derivatives to readily bind with a variety of enzymes and receptors in biological systems through diverse weak interactions, thereby exhibiting broad bioactivities. The related research and developments of imidazole-based medicinal chemistry have become a rapidly developing and increasingly active topic. The developments of imidazole-based compounds in the whole range of medicinal chemistry as anticancer, antimicrobial, anti-inflammatory, antihypertensive, antihistaminica together with their potential applications in diagnostics and pathology.Oxindole unit is a privileged heterocyclic motif that forms the core of a large family of alkaloid natural products with strong bioactivity activities such as anti-tumor, anti-anxiety, anti-inflammatory, antihypertensive, antipyretic and analgesic. In recent years, studies on the synthesis of spiro oxindole compounds have attracted more and more attention from synthetic chemists and medicinal chemists.Three chapters are included in this thesis.In the first chapter, recent progress for the syntheses of Imidazole compounds and their bioactivity evaluation were summarized.In the second chapter, the two methods for the synthesis of spiro oxindole compounds were introduced.In the third chapter, experiment procedure, physical and spectrum data for compounds described in Chapter2were recorded.