Synthesis Of 4 - Triisopropylsilyl - 1, 3 - Pentanediyl And Novel Targeted Dendritic Non - Viral Gene Carriers

objective: Panaxynol is a therapeutic drug for Alzheimer’sdisease, which have the neurotrophic and neuroprotective effects. Normally,panaxynol is separated from the Araliaceae and Panax extraction, separationis difficult. The extraction efficiency is low, the cost is high. Makingchemical synthesis Ginseng alkyne triol become an inevitable trend.4-triisopropylbiphenyl silicon-1,3-butadiyne panaxynol the key in the totalsynthesis of substrates, therefore, this paper aims to study the alkyne triolginseng chemical synthesis method.Methods：4-bromo-2-methyl-3-butyn-2-ol (Compound1)were synth-sised by reaction between2-methyl-3-butyn-2-ol and bromine underalkaline conditions of the potassium hydroxide，and. Then generated and theexcess (Triisopropylsilyl)acetylene under conditions of tributylamine andcuprous chloride,2-Methyl-6-(triisopropylsilyl)hexa-3,5-diyn-2-ol (Compo-und2)，Compound2with benzene as solvent, and heated under reflux togenerate4-triisopropylsilyl-1,3-butadiyne (Compound3). The structuresof the products were confirmed by1H NMR,13CNMR, UV.Results: Successful ginseng panaxytriol key bottom matter, yield and purityare improved significantly.Conclusion：The above method, the target product obtained in high yield and high purity Objective: To synthesize macrocyclic tetraamine1,4,7,10-tetraazacyclodod-ecane(cyclen) non-viral gene tree-likevector ploymer, and investigate its application in the dendriticvector materials Methods:In this thesis, the basic chemical rawmaterials Tris (hydroxymethyl) aminomethane and T-butylacrylate and Benzyl chloroformate butyl dicarbonate as well asmacrocyclic tetraamine1,4,7,10-tetraazacyclododecane(cyclen)were used, and the typical synthetic procedure was employed, in orderto synthesize the desired compounds Results and Conclution： The desiredproducts-cyclen and its non-viral gene vector ploymer have been obtained.The structure of sumatriptan was characterized by1H．NMR．IR andMS．The procedure developed has several advantages such as mild reactioncondition，convenient operation and easily obtained materia.