Study On The Treatment Of Temporal Lobe Epilepsy Control And The Evaluation Of Quality Of Life By

Objective:Using the method of eliminating phlegm and calming wind and Anti-Epilepsy Drugs (AEDs) both in treating temporal lobe epilepsy, to study the function of anti-epilepsy and observe the improvements of clinic symptoms,seizures monthly,unhealthy emotions and side effects of anti-epileptic drugs,to improve all the quality of life in temporal lobe epilepsy patients.Methods:The trail was randomized and controlled. We observed 45 EP patients for 3 months, who had definite temporal lobe epilepsy according to the diagnostic standard of Revised Classification Of Epilepsies And Epileptic Syndrome, Temporal Lobe Epilepsy diagnostic standard, Diagnosis And Therapeutic Effect Of Disease And Syndrome and Guiding Principle Of Clinical Research On New Drugs Of Traditional Chinese Medicine from Beijing Tiantan Hospital epilepsy outpatient,and the strict sample exclusion, rejection and shedding criteria were formulated.Under the guidance of TCM experts for many years of clinical work experience and based on previous research work of ours, treatment group was administered by the decoction with the method of eliminating phlegm and calming wind and AEDs both. Control group was administered by AEDs only. Each treatment was observed for 3 months.Self-rating serious degree, attack frequency monthly, weight changes,scale of symptoms of TCM,31-item quality of life questionnaire in epilepsy (QOLIE-31), self-rating anxiety scale (SAS),self-rating depression scale (SDS)and side effects of drugs were applied to measure the effects of two groups at both baseline and 3 months later.Meanwhile, the relationship between the disease and the observation index of the two groups of patients were analyzed.Statistical analysis using Excel database, SPSS19.0 statistical software for data processingResults:Two groups had good comparability (P>0.05) in demographic characteristic and characteristic baseline of EP. The attack frequency per month and weight changes had no statistical significance (P>0.05). Self-rating serious degree between two groups had no statistical significance (P>0.05) both at baseline and 3 months later, while had prominent statistical significance (P<0.01) before and after treatment both in two groups. Scores of clinical symptoms of TCM had no statistical significance (P>0.05) between two groups 3 months later,while had prominent statistical significance (P<0.01) compared with before both in two groups.Treatment group had lower scores of Irritable Mood, Insomnia,Much Phlegm, Semiliquid Stool,Drowsy,Depression,Tongue and Fur manifestation than control group (P<0.05) after therapy, and score of Constipation is lower significantly (P=0.003<0.01). Scores of total health status in QOL-31 had no statistics difference (P>0.05) between two groups after treating. Scores of Life Satisfaction, Energy/Fatigue,Drug Influence of treatment group is higher significantly than control group (P<0.01).The differences do not had statistical significance between groups (P>0.05) on the points of Self-Rating Depression Scale (SDS) and Self-Rating Anxiety Scale (SAS). SDS had markedly improved (P<0.01) in treatment group between before and after,while SDS also had improved (P<0.05) in control group.The differences had statistical significance in both groups (P>0.01) on the points of SAS. In correlation analysis,The total scores in TCM and QOL-31 are negative correlations (P<0.05), but the total scores in the QOL-31 with the total scores both in SDS and SAS are negative correlations significantly (P<0.01).The total scores are obviously positive correlations (P<0.01) between SDS and SAS.Severity in EEG is negative correlation (P<0.05) with the total score in QOL-31, but positive correlation with the total score in SDS(P<0.05) and SAS, in Kendall test P<0.05 and in Spearman test P<0.01.Severity in EEG has no correlation (P>0.05) with Course of disease, Seizure frequency monthly,Education degree,the total score in TCM. Course of disease has no correlation (P>0.05) with Seizure frequency monthly, Education degree,the total scores in TCM, QOL-31,SDS and SAS.Seizure frequency monthly with the score in TCM are positive correlation (P<0.05) in control group after treating, meanwhile, with others have no correlations (P>0.05) at all.The side effects of treatment group were lower than the control group (P<0.05) after treating. In this study, gastrointestinal symptoms, dizziness and drowsiness were the clinical common side effects.Conclusions:1. Effects of AEDs combined with the method of eliminating phlegm and calming wind in treating temporal lobe epilepsy which belong to the type of wind and phlegm disturbing in body are better than that of administering AEDs alone, especially in part of TCM syndromes and bad mood and improving the quality of life. The method is safe and credible to the temporal lobe epilepsy, it can also reduce some side effects of AEDs in some extent.