Study On The Correlation Between TCM Syndromes And Physicochemical Indexes In 96 Elderly Patients With Type 2 Diabetes Mellitus

Objective:TCM has significant effectiveness on the treatment of T2DMs not only in improving symptoms bul also in improving" islet function. Through analyzing the correlation between TCM syndrome, related comorbidity, complications and physical-chemical indexes, which further hinted that TCM syndrome characteristics of elderly DM and connection between different syndromes and related indicators, we were looking forward to summarize the differences between elderly DM with normal, so as to provide some implications for prevention and control of traditional Chinese medicine in elderly DM.Methods:We divided elderly patients with DM into five TCM syndromes:Yin deficiency and heat excessive syndrome, dampness and heat encumbering the spleen syndrome, qi and yin deficiency syndrome, yin and yang deficiency with Blood stasis and fluid stagnation syndrome and blood stasis in the meridians syndrome.After collecting basic clinical data of 96 patients, we used SPSS to explore the relationship of related comorbidity, complications and physical-chemical indexes between different TCM syndromes and the distribution regularities of TCM syndrome.Results:1. The proportion of TCM syndrome were arranged from high to low:Yin deficiency and heat excessive syndrome, Yin and yang deficiency syndrome with blood stasis and fluid stagnation syndrome, syndrome of blood stasis in the meridians, syndrome of qi and yin deficiency, syndrome of dampness and heat encumbering the spleen.2. The number of cases of disease course over 10 years was 68(70.8%). The differences of TCM syndrome distributions between every disease course group were significant (P<0.05).3. Compared the smoking group with the control group, there were significant differences of TCM syndrome distributions (P<0.05).While the alcohol drinking group goes the opposite (P>0.05)4. The prevalence ratio of DM macroangiopathy was the highest, followed by diabetic peripheral neuropathy, diabetic nephropathy and diabetic retinopathy.5. There were significant differences in DM macroangiopathy and CHD between every symptom group (P<0.05). And there were differences in TC between every group (P<0.05).Through pairwise comparison, differences between the Yin deficiency and heat excessive syndrome and the rest four groups had been observed. There were significant differences in LDL-C and HDL-C between every group (P<0.05). There was no significant differences in TG, HbAlc, FBS, BUN, Scr and UA between every group (P>0.05)6. In the aspect of medication, oral hypoglycemic drugs, insulin and oral. medications were widely used, α-glucosidase inhibitors, a-glucosidase inhibitor with sulfonylureas were common among oral hypoglycemic drugs; and a-glucosidase inhibitor with premixed insulin were common among insulin combined with oral medications situation.Conclusion:1. Qi and yin deficiency and Yin and yang deficiency syndrome with blood stasis and fluid stagnation syndrome are the most common syndromes in elder patients with DM mellitus2. The proportion ratio of DM macroangiopathy is the highest.The differences in TCM syndromes may have important implications in terms of implying DM complications.3. The proportion ratio of hypertension is the highest. The differences in TCM syndromes may have important implications in terms of implying fatty liver disease, coronary heart disease and cerebrovascular disease.4. In the aspect of TC, through pair wise comparison, differences between the Yin deficiency and heat excessive syndrome and the rest four groups have been observed. Therefore, TC may become one of the reference points for TCM syndrome differentiation among elderly patients with DM.5. In the aspect of medication, oral hypoglycemic drugs, insulin and oral medications are common; α-glucosidase inhibitors are widely used.