The Pharmaceutical, Pharmacodynamical And Pharmacokinemical Study On A New Type Of Transmerdal Iodin Preparation

A new type of transmerdal lodin preparation which was systhesized in a chemical way and named "XIAO VAN WANG" by my self.. In the study, a pathological instep arthritis model of dog via injection staphylococcus aureus into instep arthrosis cavity and then a pharmacodynamical test of its permeation though dog's instep arthrosis skin in vitro was performed, the clinical therapeutical effect of the praparation's was investigated by clinical scores. After that,the forward study on therapeutical effect of clinical milk cow instep arthrosis was also carried.The study on trandermal absorben pharmacokinemics of the drug was carried in rabbits by spraying over two-sides ears. After admistration to the specialized location of the ears, the blood samples were collected in a ear side vein at 0,0.5,0.75,1,1.5,2,2.5,3,3.5,4,5,6,7,8 hour. The blood plasma was harvested and stoered at 4C. lodin in the plsma was detected though Gas Chromatography.Gas Chromatography qualification-Chromatography column: SE-30 , column temperture: 100C, the mobile phase: N2(GC-grade)), flow rate: 30ml/min, Detector and Temperture: ECD, 200C.The main pharmacokinetics parameters were calculated by the of 3p97, the main parameters were LagTime, Tcp, MRT and their values were 0.42 0.18h, 1.5 0.5h,2.72 0.78h respectively.The results indicated the drug(Iodin preparation),permeated largely into blood though skin and can reach to an satisfactory therapeutical effect of the conmentioned diseases above.At the same time,we can know from the results, the drug concentration in blood also can last quite long and can make a difference in inclinical use. The pharmakynamical test results also indicated, as to the dog's arthrosis, the effective rate was about 80%, as to milk cow skin ulcer, hoof inflammation, instep arthrosis concerned diseases, the effective rate was about 64.4%.