The Study On New Medicine Fenthion Spot-on Killing Bovine Hypodermosis Larvae

To eradicate bovine hypodermosis disease Fenthion spot-on as a new medicine absorbed percutaneously was tested and exploited. Fenthion as primary medicine and high efficient cutaneous penetration enhancers which include 1,2-propylene glycol, Azone, Ethyl acetate and Ethyl acetoacetate C.P. were rationally compounded to get 5 Fenthion spot-on. After Fenthion spot-on was daubed on the back of 10 cattle, blood samples were collected and handled on different time. Fenthion density of the blood samples were measured with Gas chromatograph and compared each other. The medicine density and continuous time of 10% Fenthion spot-on in the blood samples were higher other groups, so it was selected as the best medicine group. By the research of medicine metabolism to 10% Fenthion spot-on with 2 cattle it was indicated that the highest medicine density in the blood is 10.813ng/ml on 16 hour and continuous time in which its density in the blood exceed 5ng/ml is more than 24 hours. The clinical test achieved 100% efficacy to kill bovine hypodermosis larvae with 10%.fenthion spot-on. The infection ratio of bovine hypodermosis declined from 30% to 0. Moreover, there was no one poisoned cattle. There was no one poisoned cattle when 10% Fenthion spot-on was tested with 3 times dosage. The efficacy of 10% Fenthion spot-on exceed 10% than the of Fenthion injection. Compared with Fenthion pour-on 10% Fenthion spot-on have advantages of lower cost and more convenient use.