Studies On Pharmacokinetics And Residues Of Sarafloxacin Hydrochloride In Chicken

Sarafloxacin Hydrochloride is one of floroquinolones only used for animals infectious diseases.In this thesis, the pharmacokinetics process of sarafloxacin Hydrochloride of chicken and the residue in tissue of chicken are studied by using the (High performance liquid chromatography,HPLC) procedure. The dynamic interrelated relationship of the drug level between serum and tissue were analyzed by the use of the regression analysis, and the indirectly predictive equation about the drag concentration in tissue is established. The data were analyzed with the Pharma~olinetics computer program MCP-KP. Phamiacolinetics show that the blood concentration-time course can be described with the first compartment open model with the first order absorption alter oral administration( 10mg/kg) .Its theoretical equation was as follows: CbI .036 (eI735t - e2057t), its main pharmacokinetics parameters t1,.3.793his. t...I.5807brs.. c0.7429 i g/ml.. AUC5.3790 i g/ml. h0 The kinetics process Sarafloxacin Hydrochloride in tissues: the heart concentration -time (C1-T) data of Sarafloxacin Hydrochloride was best described by a triexponential equation with flint order absorption.Its theoretical equation was as follows: Ch = 0.1455e0 43+2.484& OS44O3L2629e lS6I7t its main pharmacokinetics parameters t117.765hrs t111 .6027 tl.6826 hrs c0.5129 j.i g/ml . AUC9.0265 .t g/ml. h0 The heart concentration -time (C-T3 data of Sarafloxacin Hydrochloride was best described by a triexponential equation with first order absorption.Its theoretical equation was as -O.12&-02111t -04976t follows: Ck = I .703e +0.3283e -2.031 2e , its main pharmacokinetics parameters t1, 40.26 hrs.. t4.418hrs. t 1.9855 hrs c0.9090 i g/ml., AUC1O.894 .t g/ml. h The liver concentration -time (C1-T3 data of Sarafloxacin Hydrochloride was best described by a biexponential equation with first order absorption.Its theoretical equation was as -018103t .O1IO& follows: C1= 6.732(e - e ), its main pharmacokinetics parameters tl,2k3.1587hIS t1,1.9764hrs. c3.737 j.t gin 1.. AUC31.354 5.1 giml. h. The muscle concentration -time (C1-T1) data of Sarafloxacin Hydrochloride was best described by a biexponential equation with first order absorption.Its theoretical equation was as follows: Cm 0.91 88(e0157 - eO2OI4t) its main pharmacokinetics parameters t112k4. l24hrs-. t,3.5679hrs.. c0.6956 ji giml.. AUC5.3269 g/ml. hrs. Tissue phannacokinetics indicates Sarafloxacin Hydrochloride concentration in tissue is the highest for liver, and lower for kidney and muscle, and the lowest for the heart. And the residue time of drug in kidney is longer than that in the other tissue..According to the elimination regularity of serum. heart liver., kidney and muscle,the time taken by the drag concentration dropping to 0.OIug/ml is calculated.They were 5.58(hrs), 49.83(hrs), 32.63brs) ,160.02(hrs), 29.43(hrs). The drug concentration in serum and tissue is analyzed by the use of the liner regression equation in one unknow and multi-unkow, and the curvilinear regression equation in one unkow. The results indicate that the dynamic variation regularity of the drug concentration in serum and tissue can be better studied with this two analysis method, and the curvilinear regression is better than the linear one in entirety and accuracy.The purpose of prediction the drug concentration in tissue indirectly is achieved by the use of various regression equations.