| Microfluidic chip changing our life will become an vital technology in the future. It can be used widely in many fields,such as disease diagnosis and cure, drug genome atlas, drug screen sizing, herbal species identification, cropper selective preference, judicial, appraisement, food hygiene supervision, environmental detection, national defense and so on.Microfluidic chip also belongs to MEMS. Scientists have fabricated the microfluidic chip which can be used in biological analysis and translocation such as hypertension genotype detective chip and high efficiency capillary electropho-resis apparatus. They are applied widely in the biology and medicine fields. For instance, clinical assay, genome identification and virus detection. Compared with traditional detective method, it can largely shorten checking time which just needs a tiny sample with a high precision. Now as the polymer science advances continually, the Research on biological macromolecule(such as DNA and protein)has received lots of scientists' interests. First we need a micro-channel that controls maromolecules flowing and then we must know how these polymers flow in different kinds of micro-channels especially focusing on dynamic characteristics of DNA. In this field there is few relating research at home. The main work of this thesis is to investigate the flowing characteristics of DNA and analyze the relating force of DNA in bacteriophage. All of this research belongs to nanoscience which is a new discipline.Now several methods are used to investigate DNA dynamics. The common methods are such as MD, MC, BD, etc. MD is widely used in the commercial software which is often used in laboratory and research department of company. However, BD is one mesoscale method between MD and continuum method. The core of this paper is flowing theory of DNA in nanotube and stress anaysis in bacteriophage. The main works of this paper are as follows: 1. Understanding the present situation of microfludic field through looking up lots of literature home and abroad, We presented and compared the relating literature, and then determined the research direction.2. Comparing with different kinds of simplified DNA models we adopted one appropriate model of WLC to investigate the motion process of DNA in static aqueous solution assuming such motion obeying brownian motion and then compared with theoretical equations testifying the correctness of our model.3. By debugging the program repeatedly, this paper chose two sets of reasonable bead-rod model parameters: (1) a=2nm, b=10nm; (2) a=1.59nm; b=3.18nm.4. Having described the advantages of computer simulation, one comparison was done among BD, MC and MD. Deep research of BD which is used to stimulate the DNA dynamics in nanotube also had been done.5. Proposing two methods deal with representing virtual Wall: one is stochastic method to adapt displacement in every iterative step, the other one is Lennard-Jones potential method. The latter is more convenient to be inserted in Brownian motion equation and by this way there no such a problem that bead penetrates the wall compared with the former.6. We investigated all kinds of DNA profiles in capsid, and then mainly investigated the relationship among the energy of DNA, the pressure in capsid and the length that was packaged.7. Four classical types of phages (λ,Φ29, T7, T4) which correspond to three simplified models had been selected to be discussed in this paper in order to get their characteristics through comparison and analysis in chapter 4.The content of this paper belonging to the field of microfluidics will be greatly helpful for the future's research of DNA dynamics. .
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